Emergence and predominance of an H5N1 influenza variant in China

G. J.D. Smith, X. H. Fan, J. Wang, K. S. Li, K. Qin, J. X. Zhang, D. Vijaykrishna, C. L. Cheung, Kai Huang, J. M. Rayner, J. S.M. Peiris, H. Chen, R. G. Webster, Y. Guan

Research output: Contribution to journalArticle

256 Citations (Scopus)

Abstract

The development of highly pathogenic avian H5N1 influenza viruses in poultry in Eurasia accompanied with the increase in human infection in 2006 suggests that the virus has not been effectively contained and that the pandemic threat persists. Updated virological and epidemiological findings from our market surveillance in southern China demonstrate that H5N1 influenza viruses continued to be panzootic in different types of poultry. Genetic and antigenic analyses revealed the emergence and predominance of a previously uncharacterized H5W1 virus sublineage (Fujian-like) in poultry since late 2005. Viruses from this sublineage gradually replaced those multiple regional distinct sublineages and caused recent human infection in China. These viruses have already transmitted to Hong Kong, Laos, Malaysia, and Thailand, resulting in a new transmission and outbreak wave in Southeast Asia. Serological studies suggest that H5W1 seroconversion in market poultry is low and that vaccination may have facilitated the selection of the Fujian-like sublineage. The predominance of this virus over a large geographical region within a short period directly challenges current disease control measures.

Original languageEnglish (US)
Pages (from-to)16936-16941
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number45
DOIs
StatePublished - Nov 7 2006
Externally publishedYes

Fingerprint

Human Influenza
China
Poultry
Viruses
H5N1 Subtype Influenza A Virus
Orthomyxoviridae
Laos
Southeastern Asia
Influenza in Birds
Malaysia
Hong Kong
Pandemics
Thailand
Infection
Disease Outbreaks
Vaccination

Keywords

  • Influenza A
  • Molecular epidemiology
  • Virus evolution

ASJC Scopus subject areas

  • General

Cite this

Emergence and predominance of an H5N1 influenza variant in China. / Smith, G. J.D.; Fan, X. H.; Wang, J.; Li, K. S.; Qin, K.; Zhang, J. X.; Vijaykrishna, D.; Cheung, C. L.; Huang, Kai; Rayner, J. M.; Peiris, J. S.M.; Chen, H.; Webster, R. G.; Guan, Y.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 45, 07.11.2006, p. 16936-16941.

Research output: Contribution to journalArticle

Smith, GJD, Fan, XH, Wang, J, Li, KS, Qin, K, Zhang, JX, Vijaykrishna, D, Cheung, CL, Huang, K, Rayner, JM, Peiris, JSM, Chen, H, Webster, RG & Guan, Y 2006, 'Emergence and predominance of an H5N1 influenza variant in China', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 45, pp. 16936-16941. https://doi.org/10.1073/pnas.0608157103
Smith, G. J.D. ; Fan, X. H. ; Wang, J. ; Li, K. S. ; Qin, K. ; Zhang, J. X. ; Vijaykrishna, D. ; Cheung, C. L. ; Huang, Kai ; Rayner, J. M. ; Peiris, J. S.M. ; Chen, H. ; Webster, R. G. ; Guan, Y. / Emergence and predominance of an H5N1 influenza variant in China. In: Proceedings of the National Academy of Sciences of the United States of America. 2006 ; Vol. 103, No. 45. pp. 16936-16941.
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