Emergence of anthrax edema toxin as a master manipulator of macrophage and B cell functions

Bryan T. Gnade, Scott T. Moen, Ashok K. Chopra, Johnny W. Peterson, Linsey A. Yeager

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Anthrax edema toxin (ET), a powerful adenylyl cyclase, is an important virulence factor of Bacillus anthracis. Until recently, only a modest amount of research was performed to understand the role this toxin plays in the organism's immune evasion strategy. A new wave of studies have begun to elucidate the effects this toxin has on a variety of host cells. While efforts have been made to illuminate the effect ET has on cells of the adaptive immune system, such as T cells, the greatest focus has been on cells of the innate immune system, particularly the macrophage. Here we discuss the immunoevasive activities that ET exerts on macrophages, as well as new research on the effects of this toxin on B cells.

Original languageEnglish (US)
Pages (from-to)1881-1897
Number of pages17
JournalToxins
Volume2
Issue number7
DOIs
StatePublished - Jul 1 2010

Keywords

  • Anthrax
  • B cell
  • CAMP signaling
  • Edema toxin
  • Macrophage

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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