Emergence of epidemic zika virus transmission and congenital zika syndrome

Are recently evolved traits to blame?

Research output: Contribution to journalComment/debate

24 Citations (Scopus)

Abstract

The mechanisms responsible for the dramatic emergence of Zika virus (ZIKV), accompanied by congenital Zika syndrome and Guillain-Barré syndrome (GBS), remain unclear. However, two hypotheses are prominent: (i) evolution for enhanced urban transmission via adaptation to mosquito vectors, or for enhanced human infection to increase amplification, or (ii) the stochastic introduction of ZIKV into large, naive human populations in regions with abundant Aedes aegypti populations, leading to enough rare, severe infection outcomes for their first recognition. Advances in animal models for human infection combined with improvements in serodiagnostics, better surveillance, and reverse genetic approaches should provide more conclusive evidence of whether mosquito transmission or human pathogenesis changed coincidentally with emergence in the South Pacific and the Americas. Ultimately, understanding the mechanisms of epidemic ZIKV emergence, and its associated syndromes, is critical to predict future risks as well as to target surveillance and control measures in key locations.

Original languageEnglish (US)
Article numbere02063-16
JournalmBio
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2017

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Infection
Reverse Genetics
South America
Aedes
Culicidae
Population
Animal Models
Zika Virus
Mosquito Vectors

ASJC Scopus subject areas

  • Microbiology
  • Virology

Cite this

Emergence of epidemic zika virus transmission and congenital zika syndrome : Are recently evolved traits to blame? / Weaver, Scott.

In: mBio, Vol. 8, No. 1, e02063-16, 01.01.2017.

Research output: Contribution to journalComment/debate

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