Emergence of genotype I of Japanese encephalitis virus as the dominant genotype in Asia

Xiao Ling Pan, Hong Liu, Huan Yu Wang, Shi Hong Fu, Hai Zhou Liu, Hai Lin Zhang, Ming Hua Li, Xiao Yan Gao, Jing Lin Wang, Xiao Hong Sun, Xin Jun Lu, You Gang Zhai, Wei Shan Meng, Ying He, Huan Qin Wang, Na Han, Bo Wei, Yong Gan Wu, Yun Feng, Du Juan YangLi Hua Wang, Qin Tang, Guoliang Xia, Ichiro Kurane, Simon Rayner, Guo Dong Liang

Research output: Contribution to journalArticlepeer-review

143 Scopus citations

Abstract

Japanese encephalitis virus (JEV), a mosquito-borne zoonotic pathogen, is one of the major causes of viral encephalitis worldwide. Previous phylogenetic studies based on the envelope protein indicated that there are four genotypes, and surveillance data suggest that genotype I is gradually replacing genotype III as the dominant strain. Here we report an evolutionary analysis based on 98 full-length genome sequences of JEV, including 67 new samples isolated from humans, pigs, mosquitoes, midges. and bats in affected areas. To investigate the relationships between the genotypes and the significance of genotype I in recent epidemics, we estimated evolutionary rates, ages of common ancestors, and population demographics. Our results indicate that the genotypes diverged in the order IV, III, II, and I and that the genetic diversity of genotype III has decreased rapidly while that of genotype I has increased gradually, consistent with its emergence as the dominant genotype.

Original languageEnglish (US)
Pages (from-to)9847-9853
Number of pages7
JournalJournal of virology
Volume85
Issue number19
DOIs
StatePublished - Oct 2011
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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