Emerging and re-emerging Rickettsioses

Endothelial cell infection and early disease events

David Walker, Nahed Ismail

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Rickettsiae cause some of the most severe human infections, including epidemic typhus and Rocky Mountain spotted fever. Substantial progress has been made in research into the genomics, vector relationships, pathogenesis and immunity of these obligate, intracellular, arthropod-transmitted bacteria. This Review summarizes our understanding of the early and late events in pathogenesis and immunity, modulation of the host response to rickettsial infection by the vector, host defence, virulence mechanisms and rickettsial manipulation of host cells.

Original languageEnglish
Pages (from-to)375-386
Number of pages12
JournalNature Reviews Microbiology
Volume6
Issue number5
DOIs
StatePublished - May 2008

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Immunity
Endothelial Cells
Rocky Mountain Spotted Fever
Epidemic Louse-Borne Typhus
Rickettsia
Arthropods
Genomics
Infection
Virulence
Bacteria
Research

ASJC Scopus subject areas

  • Microbiology

Cite this

Emerging and re-emerging Rickettsioses : Endothelial cell infection and early disease events. / Walker, David; Ismail, Nahed.

In: Nature Reviews Microbiology, Vol. 6, No. 5, 05.2008, p. 375-386.

Research output: Contribution to journalArticle

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