TY - JOUR
T1 - Emerging and Re-emerging Tick-Transmitted Rickettsial and Ehrlichial Infections
AU - Walker, David H.
AU - Paddock, Christopher D.
AU - Dumler, J. Stephen
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/11
Y1 - 2008/11
N2 - Recently in the field of rickettsiology, an explosion of new isolates of pathogens have received species designation and new disease names, all of which have been relatively neglected by primary care and infectious disease physicians. A broad group of other tick-associated rickettsial and ehrlichial agents of unknown pathogenicity exist (eg, R amblyommii) that may cause confusion in interpreting serologic surveys or a single elevated antibody titer. Rickettsial and ehrlichial diseases are remarkable for their uniform susceptibility to doxycycline but are clinically difficult to distinguish from many viral infections and each another, and therefore misdiagnosis and failure to treat have unfortunate and sometimes tragic outcomes. Globally, many of these bacteria have been named but the genetic differences among them are often small, and many of their clinical manifestations may not be distinguishable diagnostically.
AB - Recently in the field of rickettsiology, an explosion of new isolates of pathogens have received species designation and new disease names, all of which have been relatively neglected by primary care and infectious disease physicians. A broad group of other tick-associated rickettsial and ehrlichial agents of unknown pathogenicity exist (eg, R amblyommii) that may cause confusion in interpreting serologic surveys or a single elevated antibody titer. Rickettsial and ehrlichial diseases are remarkable for their uniform susceptibility to doxycycline but are clinically difficult to distinguish from many viral infections and each another, and therefore misdiagnosis and failure to treat have unfortunate and sometimes tragic outcomes. Globally, many of these bacteria have been named but the genetic differences among them are often small, and many of their clinical manifestations may not be distinguishable diagnostically.
KW - Ehrlichia ewingii
KW - Human granulocytotropic anaplasmosis
KW - Human monocytotropic ehrlichiosis
KW - Rickettsia parkeri
KW - Rocky Mountain spotted fever
KW - Typhus
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U2 - 10.1016/j.mcna.2008.06.002
DO - 10.1016/j.mcna.2008.06.002
M3 - Review article
C2 - 19061755
AN - SCOPUS:54949092874
SN - 0025-7125
VL - 92
SP - 1345
EP - 1361
JO - Medical Clinics of North America
JF - Medical Clinics of North America
IS - 6
ER -