Emerging need of pharmacokinetics in Ayurvedic system of medicine

Ilango Kaliappan, Ananth Kumar Kammalla, Mohan Kumar Ramasamy, Aruna Agrawal, Govind Prasad Dubey

Research output: Contribution to journalReview articlepeer-review

Abstract

Ayurveda is the most ancient system of traditional medicine of the world has been practicing in India. It has been facing constant challenges like standardization and pharmacokinetic profile of biomarkers in the Ayurvedic formulations. Due to these challenges there will be a potential decrease in the global herbal market. Presently Indian herbal market is about US $1.1 billion whereas Chinese herbal market is about US $10 billion per annum. Thus there is an urgent need of standardization and pharmacokinetics of the Ayurvedic formulations in order to achieve the uphold position in the global market. Pharmacokinetics which deals with the absorption, distribution, metabolism and excretion of the biomarkers or the new drug entity is the one of the regulatory requirement for an investigational new drug approval. Bioactive guided pharmacokinetic approach method is needed for Ayurvedic system of medicine to determine the pharmacokinetics of relevant markers in the formulation having number of markers. Also non compartmental analysis method should be applied for the analysis of pharmacokinetics of biomarkers from Ayurvedic formulations for successful pharmacokinetic evaluation. In this review we have explored the importance of pharmacokinetics in Ayurvedic system of medicine and integrated approaches for the pharmacokinetics in Ayurvedic system of medicine.

Original languageEnglish (US)
Pages (from-to)647-651
Number of pages5
JournalInternational Journal of Research in Ayurveda and Pharmacy
Volume4
Issue number5
DOIs
StatePublished - Sep 2013
Externally publishedYes

Keywords

  • Ayurveda
  • Herbal market
  • Non compartmental model
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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