Emerging role of antioxidants in the protection of uveitis complications

U. C S Yadav, N. M. Kalariya, Kota Ramana

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Current understanding of the role of oxidative stress in ocular inflammatory diseases indicates that antioxidant therapy may be important to optimize the treatment. Recently investigated antioxidant therapies for ocular inflammatory diseases include various vitamins, plant products and reactive oxygen species scavengers. Oxidative stress plays a causative role in both non-infectious and infectious uveitis complications, and novel strategies to diminish tissue damage and dysfunction with antioxidant therapy may ameliorate visual complications. Preclinical studies with experimental animals and cultured cells demonstrate significant anti-inflammatory effects of a number of promising antioxidant agents. Many of these antioxidants are under clinical trial for various inflammatory diseases other than uveitis such as cardiovascular, rheumatoid arthritis and cancer. Well planned interventional clinical studies in the filed of ocular inflammation will be necessary to sufficiently investigate the potential medical benefits of antioxidant therapies for uveitis. This review summarizes the recent investigations of novel antioxidant agents for ocular inflammation, with selected studies focused on uveitis.

Original languageEnglish (US)
Pages (from-to)931-942
Number of pages12
JournalCurrent Medicinal Chemistry
Volume18
Issue number6
DOIs
StatePublished - Feb 2011

Fingerprint

Uveitis
Antioxidants
Oxidative stress
Eye Diseases
Oxidative Stress
Inflammation
Therapeutics
Vitamins
Cultured Cells
Reactive Oxygen Species
Rheumatoid Arthritis
Animals
Anti-Inflammatory Agents
Cells
Clinical Trials
Tissue
Neoplasms

Keywords

  • Antioxidants
  • Eye
  • Ocular inflammation
  • Oxidative stress and uveitis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Emerging role of antioxidants in the protection of uveitis complications. / Yadav, U. C S; Kalariya, N. M.; Ramana, Kota.

In: Current Medicinal Chemistry, Vol. 18, No. 6, 02.2011, p. 931-942.

Research output: Contribution to journalArticle

Yadav, U. C S ; Kalariya, N. M. ; Ramana, Kota. / Emerging role of antioxidants in the protection of uveitis complications. In: Current Medicinal Chemistry. 2011 ; Vol. 18, No. 6. pp. 931-942.
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