TY - JOUR
T1 - Emerging roles of Fgf14 in behavioral control
AU - Hoxha, Eriola
AU - Marcinnò, Andrea
AU - Montarolo, Francesca
AU - Masante, Linda
AU - Balbo, Ilaria
AU - Ravera, Francesco
AU - Laezza, Fernanda
AU - Tempia, Filippo
N1 - Funding Information:
The research was funded by a grant of the University of Torino (Local Research Grant, FY 2015 ). There are no potential conflicts of interest to declare.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Sexual disturbances, and aggressivity are a major social problem. However, the molecular mechanisms involved in the control of these behaviors are largely unknown. FGF14, which is an intracellular protein controlling neuronal excitability and synaptic transmission, has been implied in neurologic and psychiatric disorders. Mice with Fgf14 deletion show blunted responses to drugs of abuse. By behavioral tests we show that male Fgf14 knockout mice have a marked reduction of several behaviors including aggressivity and sexual behavior. Other behaviors driven by spontaneous initiative like burying novel objects and spontaneous digging and climbing are also reduced in Fgf14 knockout mice. These deficits cannot be attributed to a generalized decrease of activity levels, because in the open field test Fgf14 knockout mice have the same spontaneous locomotion as wild types and increased rearing. Our results show that Fgf14 is important to preserve a set of behaviors and suggest that fine tuning of neuronal function by Fgf14 is an important mechanism of control for such behaviors.
AB - Sexual disturbances, and aggressivity are a major social problem. However, the molecular mechanisms involved in the control of these behaviors are largely unknown. FGF14, which is an intracellular protein controlling neuronal excitability and synaptic transmission, has been implied in neurologic and psychiatric disorders. Mice with Fgf14 deletion show blunted responses to drugs of abuse. By behavioral tests we show that male Fgf14 knockout mice have a marked reduction of several behaviors including aggressivity and sexual behavior. Other behaviors driven by spontaneous initiative like burying novel objects and spontaneous digging and climbing are also reduced in Fgf14 knockout mice. These deficits cannot be attributed to a generalized decrease of activity levels, because in the open field test Fgf14 knockout mice have the same spontaneous locomotion as wild types and increased rearing. Our results show that Fgf14 is important to preserve a set of behaviors and suggest that fine tuning of neuronal function by Fgf14 is an important mechanism of control for such behaviors.
KW - Aggressivity
KW - Fgf14
KW - Mouse
KW - Sexual behavior
KW - Sociability
KW - Spontaneous behavior
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U2 - 10.1016/j.bbr.2018.08.034
DO - 10.1016/j.bbr.2018.08.034
M3 - Article
C2 - 30189289
AN - SCOPUS:85053119761
SN - 0166-4328
VL - 356
SP - 257
EP - 265
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -