@article{3e603d11f8344b7b85656e744b0a3004,
title = "Emerging roles of RNA-binding proteins in diabetes and their therapeutic potential in diabetic complications",
abstract = "Diabetes is a debilitating health care problem affecting 422 million people around the world. Diabetic patients suffer from multisystemic complications that can cause mortality and morbidity. Recent advancements in high-throughput next-generation RNA-sequencing and computational algorithms led to the discovery of aberrant posttranscriptional gene regulatory programs in diabetes. However, very little is known about how these regulatory programs are mis-regulated in diabetes. RNA-binding proteins (RBPs) are important regulators of posttranscriptional RNA networks, which are also dysregulated in diabetes. Human genetic studies provide new evidence that polymorphisms and mutations in RBPs are linked to diabetes. Therefore, we will discuss the emerging roles of RBPs in abnormal posttranscriptional gene expression in diabetes. Questions that will be addressed are: Which posttranscriptional mechanisms are disrupted in diabetes? Which RBPs are responsible for such changes under diabetic conditions? How are RBPs altered in diabetes? How does dysregulation of RBPs contribute to diabetes? Can we target RBPs using RNA-based methods to restore gene expression profiles in diabetic patients? Studying the evolving roles of RBPs in diabetes is critical not only for a comprehensive understanding of diabetes pathogenesis but also to design RNA-based therapeutic approaches for diabetic complications. WIREs RNA 2018, 9:e1459. doi: 10.1002/wrna.1459. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Processing > Splicing Regulation/Alternative Splicing Translation > Translation Regulation.",
author = "Nutter, {Curtis A.} and Kuyumcu-Martinez, {Muge N.}",
note = "Funding Information: UTMB Kempner Fellowship; National Institutes of Health/National Heart Lung Blood Institute, Grant/ Award number: 1R01HL135031-01; UTMB Department of Biochemistry and Molecular Biology Bridging funds; American Heart Association, Grant/Award number: 15GRNT22830010 Funding Information: We thank Kuyumcu-Martinez lab members for reading the manuscript and Dr Heather Lander for editing the manuscript. Graphics were downloaded from Servier Medical Art under a Creative Commons Attribution 3.0 Unported License. We apologize to authors whose works have not been cited due to the space constraints. This work was supported, in part, by an American Heart Association Grant (15GRNT22830010); UTMB Department of Biochemistry and Molecular Biology Bridging funds; and a grant from the National Institutes of Health/National Heart Lung Blood Institute (1R01HL135031-01) to M.N.K-M. C.A.N. was supported by UTMB Kempner Fellowship. Funding Information: We thank Kuyumcu-Martinez lab members for reading the manuscript and Dr Heather Lander for editing the manuscript. Graphics were downloaded from Servier Medical Art under a Creative Commons Attribution 3.0 Unported License. We apologize to authors whose works have not been cited due to the space constraints. This work was supported, in part, by an American Heart Association Grant (15GRNT22830010); UTMB Department of Biochemistry and Molecular Biology Bridging funds; and a grant from the National Institutes of Health/National Heart Lung Blood Institute (1R01HL135031-01) to M.N.K-M. C.A.N. was supported by UTMB Kempner Fellowship. The authors have declared no conflicts of interest for this article. Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",
year = "2018",
month = mar,
day = "1",
doi = "10.1002/wrna.1459",
language = "English (US)",
volume = "9",
journal = "Wiley Interdisciplinary Reviews: RNA",
issn = "1757-7004",
publisher = "John Wiley and Sons Inc.",
number = "2",
}