Emerging roles of SIRT6 in human diseases and its modulators

Gang Liu, Haiying Chen, Hua Liu, Wenbo Zhang, Jia Zhou

Research output: Contribution to journalReview articlepeer-review

Abstract

The biological functions of sirtuin 6 (SIRT6; e.g., deacetylation, defatty-acylation, and mono-ADP-ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene expression, and telomeric maintenance. Over the past decades, the aberration of SIRT6 has been extensively observed in diverse life-threatening human diseases. In this comprehensive review, we summarize the critical roles of SIRT6 in the onset and progression of human diseases including cancer, inflammation, diabetes, steatohepatitis, arthritis, cardiovascular diseases, neurodegenerative diseases, viral infections, renal and corneal injuries, as well as the elucidation of the related signaling pathways. Moreover, we discuss the advances in the development of small molecule SIRT6 modulators including activators and inhibitors as well as their pharmacological profiles toward potential therapeutics for SIRT6-mediated diseases.

Original languageEnglish (US)
Pages (from-to)1089-1137
Number of pages49
JournalMedicinal Research Reviews
Volume41
Issue number2
DOIs
StatePublished - Mar 2021

Keywords

  • SIRT6
  • activators
  • deacetylation
  • defatty-acylation
  • human diseases
  • inhibitors
  • mono-ADP-ribosylation
  • small molecule modulators

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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