Emerging tick-borne infections in mainland China: An increasing public health threat

Li Qun Fang, Kun Liu, Xin Lou Li, Song Liang, Yang Yang, Hong Wu Yao, Ruo Xi Sun, Ye Sun, Wan Jun Chen, Shu Qing Zuo, Mai Juan Ma, Hao Li, Jia Fu Jiang, Wei Liu, X. Frank Yang, Gregory C. Gray, Peter J. Krause, Wu Chun Cao

Research output: Contribution to journalReview articlepeer-review

218 Scopus citations


Since the beginning of the 1980s, 33 emerging tick-borne agents have been identified in mainland China, including eight species of spotted fever group rickettsiae, seven species in the family Anaplasmataceae, six genospecies in the complex Borrelia burgdorferi sensu lato, 11 species of Babesia, and the virus causing severe fever with thrombocytopenia syndrome. In this Review we have mapped the geographical distributions of human cases of infection. 15 of the 33 emerging tick-borne agents have been reported to cause human disease, and their clinical characteristics have been described. The non-specific clinical manifestations caused by tick-borne pathogens present a major diagnostic challenge and most physicians are unfamiliar with the many tick-borne diseases that present with non-specific symptoms in the early stages of the illness. Advances in and application of modern molecular techniques should help with identification of emerging tick-borne pathogens and improve laboratory diagnosis of human infections. We expect that more novel tick-borne infections in ticks and animals will be identified and additional emerging tick-borne diseases in human beings will be discovered.

Original languageEnglish (US)
Pages (from-to)1467-1479
Number of pages13
JournalThe Lancet Infectious Diseases
Issue number12
StatePublished - Dec 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases


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