En face imaging of the choroid in polypoidal choroidal vasculopathy using swept-source optical coherence tomography

Tarek Alasil, Daniela Ferrara, Mehreen Adhi, Erika Brewer, Martin F. Kraus, Caroline R. Baumal, Joachim Hornegger, James G. Fujimoto, Andre J. Witkin, Elias Reichel, Jay S. Duker, Nadia K. Waheed

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Objective To define morphologic features of polypoidal choroidal vasculopathy (PCV) using en face images from swept-source optical coherence tomography (SS OCT). Design Prospective cross-sectional study. Methods The study included 10 eyes from 6 patients with PCV and 10 eyes from 5 age-matched normal subjects. All subjects were prospectively scanned with a prototype SS OCT system. A motion correction algorithm was applied to correct and merge scans into a single volumetric dataset. En face images were generated at intervals of 4.13 μm (1 pixel) relative to the Bruch membrane. Results Age ± standard deviation for the normal group was 62.4 (±12.1) years and for the PCV group was 68.3 (±5.2) years. En face SS OCT imaging of PCV eyes demonstrated the relationship between larger pigment epithelial detachments (PEDs) and small adjoining PEDs that correlated with the polypoidal lesions seen on indocyanine green angiography in all PCV eyes. En face SS OCT demonstrated choroidal vascular abnormalities in 7 out of 7 eyes with PCV, and in 2 out of 3 enrolled fellow eyes in patients with unilateral PCV. Out of 7 PCV eyes, focal choroidal vascular dilation was noted in 3 eyes and diffuse choroidal vascular dilation was noted in 1 eye. In addition, a branching vascular network was noted above the Bruch membrane in 1 eye, below the Bruch membrane within the choriocapillaris in 1 eye, and in the larger choroidal vascular layer in 1 eye. Conclusions En face SS OCT provides an in vivo tool to visualize the pathologic features and the choroidal vasculature in PCV.

Original languageEnglish (US)
Pages (from-to)634-643
Number of pages10
JournalAmerican Journal of Ophthalmology
Issue number4
StatePublished - Apr 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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