@inbook{a0f290e8c79a44dfb8963f3e4b3b0f18,
title = "Enantioseparation and detection of (R)-2-hydroxyglutarate and (S)-2-hydroxyglutarate by chiral gas chromatography–triple quadrupole mass spectrometry",
abstract = "(R)-2-hydroxyglutarate (R-2-hg) has gained significant interest as a circulating biomarker for patients with cancers that harbor mutations in the isocitrate dehydrogenase (IDH) gene. R-2-hg detection is challenging as it must be separated from its enantiomer, (S)-2-hydroxyglutarate (S-2-hg). Here, we present a novel gas chromatography–tandem mass spectrometry method (GC-MS/MS) assay that can be used to separate and detect 2-hg enantiomers for clinical use.",
keywords = "2-hydroxyglutarate enantiomer, Acute Myeloid Leukemia, Chiral Chromatography, Cholangiocarcinoma, Gas chromatography–tandem mass spectrometry, Glioma, Isocitrate dehydrogenase, Serum, Urine",
author = "Strain, {Shinji K.} and Groves, {Morris D.} and Emmett, {Mark R.}",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2021.",
year = "2021",
doi = "10.1007/978-1-0716-0864-7_8",
language = "English (US)",
series = "Neuromethods",
publisher = "Humana Press Inc.",
pages = "89--100",
booktitle = "Neuromethods",
}