@inbook{a0f290e8c79a44dfb8963f3e4b3b0f18,
title = "Enantioseparation and detection of (R)-2-hydroxyglutarate and (S)-2-hydroxyglutarate by chiral gas chromatography–triple quadrupole mass spectrometry",
abstract = "(R)-2-hydroxyglutarate (R-2-hg) has gained significant interest as a circulating biomarker for patients with cancers that harbor mutations in the isocitrate dehydrogenase (IDH) gene. R-2-hg detection is challenging as it must be separated from its enantiomer, (S)-2-hydroxyglutarate (S-2-hg). Here, we present a novel gas chromatography–tandem mass spectrometry method (GC-MS/MS) assay that can be used to separate and detect 2-hg enantiomers for clinical use.",
keywords = "2-hydroxyglutarate enantiomer, Acute Myeloid Leukemia, Chiral Chromatography, Cholangiocarcinoma, Gas chromatography–tandem mass spectrometry, Glioma, Isocitrate dehydrogenase, Serum, Urine",
author = "Strain, {Shinji K.} and Groves, {Morris D.} and Emmett, {Mark R.}",
note = "Funding Information: This work was supported by The Shimadzu Corporation and The Head for The Cure Foundation. SKS was supported by The Institute for Translational Sciences at The University of Texas Medical Branch, supported, in part, by a Clinical and Translational Science Award NRSA (TL1) Training Core (TL1TR001440) from the National Center for Advancing Translational Sciences, National Institutes of Health. Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2021.",
year = "2021",
doi = "10.1007/978-1-0716-0864-7_8",
language = "English (US)",
series = "Neuromethods",
publisher = "Humana Press Inc.",
pages = "89--100",
booktitle = "Neuromethods",
}