Endemic Venezuelan equine encephalitis in the Americas: Hidden under the dengue umbrella

Patricia Aguilar, Jose G. Estrada-Franco, Roberto Navarro-Lopez, Cristina Ferro, Andrew D. Haddow, Scott Weaver

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Venezuelan equine encephalitis (VEE) is an emerging infectious disease in Latin America. Outbreaks have been recorded for decades in countries with enzootic circulation, and the recent implementation of surveillance systems has allowed the detection of additional human cases in countries and areas with previously unknown VEE activity. Clinically, VEE is indistinguishable from dengue and other arboviral diseases and confirmatory diagnosis requires the use of specialized laboratory tests that are difficult to afford in resource-limited regions. Thus, the disease burden of endemic VEE in developing countries remains largely unknown, but recent surveillance suggests that it may represent up to 10% of the dengue burden in neotropical cities, or tens-of-thousands of cases per year throughout Latin America. The potential emergence of epizootic viruses from enzootic progenitors further highlights the need to strengthen surveillance activities, identify mosquito vectors and reservoirs and develop effective strategies to control the disease. In this article, we provide an overview of the current status of endemic VEE that results from spillover of the enzootic cycles, and we discuss public health measures for disease control as well as future avenues for VEE research.

Original languageEnglish (US)
Pages (from-to)721-740
Number of pages20
JournalFuture Virology
Volume6
Issue number6
DOIs
StatePublished - Jun 2011

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Venezuelan Equine Encephalomyelitides
Dengue
Latin America
Emerging Communicable Diseases
Endemic Diseases
Developing Countries
Disease Outbreaks
Public Health
Viruses
Research

Keywords

  • alphavirus
  • encephalitis
  • endemic
  • epizootic
  • mosquito
  • surveillance

ASJC Scopus subject areas

  • Virology

Cite this

Endemic Venezuelan equine encephalitis in the Americas : Hidden under the dengue umbrella. / Aguilar, Patricia; Estrada-Franco, Jose G.; Navarro-Lopez, Roberto; Ferro, Cristina; Haddow, Andrew D.; Weaver, Scott.

In: Future Virology, Vol. 6, No. 6, 06.2011, p. 721-740.

Research output: Contribution to journalArticle

Aguilar, Patricia ; Estrada-Franco, Jose G. ; Navarro-Lopez, Roberto ; Ferro, Cristina ; Haddow, Andrew D. ; Weaver, Scott. / Endemic Venezuelan equine encephalitis in the Americas : Hidden under the dengue umbrella. In: Future Virology. 2011 ; Vol. 6, No. 6. pp. 721-740.
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