Endocrine disruptive effects of polychlorinated aromatic hydrocarbons on intestinal cholecystokinin in rats

Heung Man Lee, Qin He, Ella Englander, George H. Greeley

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The ubiquitous and persistent nature of polychlorinated aromatic hydrocarbons (PCAHs) in our environment and the risk of exposure to PCAHs have provoked concern over their potential toxicity. In humans, exposure to PCAHs is aimed chiefly at epithelial cells residing in the intestinal mucosa, because oral intake of contaminated food is a major source of PCAHs. The purpose of this study, therefore, was to examine the effects of chronic exposure to various PCAHs [i.e. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), 3,3′,4,4′1,5-pentachlorobiphenyl (PCB-126), and 2,2′4,4′5,5′-hexachlorobiphenyl (PCB-153)], given alone or as mixtures, on intestinal cholecystokinin (CCK) peptide and messenger RNA levels. We show that chronic PCAH treatment significantly lowers intestinal levels of stored CCK peptide. Intestinal CCK messenger RNA levels are not affected. In addition, 3,3′,4,4′,5-pentachlorobiphenyl treatment increased intestinal insulin-like growth factor-binding protein-3 levels in a dose-related manner. Acute 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment of intestinal CCK cells lowered levels of CCK-processing enzymes (i.e. prohormone convertase-1 and -2). Together, these data indicate that PCAHs may decrease intestinal levels of stored CCK peptide by affecting the intestinal insulin-like growth factor system and CCK processing.

Original languageEnglish (US)
Pages (from-to)2938-2944
Number of pages7
JournalEndocrinology
Volume141
Issue number8
DOIs
StatePublished - 2000

Fingerprint

Aromatic Hydrocarbons
Cholecystokinin
3,4,5,3',4'-pentachlorobiphenyl
2,4,5,2',4',5'-hexachlorobiphenyl
Peptides
Proprotein Convertase 2
Proprotein Convertase 1
Messenger RNA
Insulin-Like Growth Factor Binding Protein 3
Somatomedins
Intestinal Mucosa
Eating
Epithelial Cells
Enzymes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Endocrine disruptive effects of polychlorinated aromatic hydrocarbons on intestinal cholecystokinin in rats. / Lee, Heung Man; He, Qin; Englander, Ella; Greeley, George H.

In: Endocrinology, Vol. 141, No. 8, 2000, p. 2938-2944.

Research output: Contribution to journalArticle

Lee, Heung Man ; He, Qin ; Englander, Ella ; Greeley, George H. / Endocrine disruptive effects of polychlorinated aromatic hydrocarbons on intestinal cholecystokinin in rats. In: Endocrinology. 2000 ; Vol. 141, No. 8. pp. 2938-2944.
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