Endocrine maturation and lung function in premature neonates of women with diabetes

C. R. Parker, J. C. Hauth, Gary Hankins, K. Leveno, C. R. Rosenfeld, J. C. Porter, P. C. MacDonald

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Because respiratory distress syndrome may result, in part, from a hormonal deficiency in the developing fetus, we investigated the endocrine milieu of 28 infants of women with diabetes who were delivered prematurely (34 to 37 weeks of gestation). The umbilical serum concentrations of estrone, estradiol, estriol, cortisol, and prolactin in infants of women with diabetes who developed respiratory distress syndrome (n = 6) were lower than those in infants of women with diabetes who had normal lung function. Serum hormone levels in age-matched newborns of normal women were higher than those in the infants of women with diabetes with respiratory distress syndrome but were not different than those in the infants of women with diabetes with normal lung function. Plasma glucose levels were highest in women whose neonates developed respiratory distress syndrome. An inverse correlation existed between maternal glucose levels and lecithin-sphingomyelin ratios in amniotic fluid. Thus diabetes occasionally results in significantly delayed maturation of the fetal endocrine milieu. In these instances, delayed fetal lung maturation is a frequent occurrence. Moreover, both phenomena may be related to the extent of diabetic control during pregnancy.

Original languageEnglish (US)
Pages (from-to)657-662
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume160
Issue number3
StatePublished - 1989
Externally publishedYes

Fingerprint

Newborn Infant
Lung
Umbilicus
Glucose
Pregnancy
Estriol
Sphingomyelins
Lecithins
Estrone
Amniotic Fluid
Serum
Prolactin
Hydrocortisone
Estradiol
Fetus
Mothers
Hormones

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Parker, C. R., Hauth, J. C., Hankins, G., Leveno, K., Rosenfeld, C. R., Porter, J. C., & MacDonald, P. C. (1989). Endocrine maturation and lung function in premature neonates of women with diabetes. American Journal of Obstetrics and Gynecology, 160(3), 657-662.

Endocrine maturation and lung function in premature neonates of women with diabetes. / Parker, C. R.; Hauth, J. C.; Hankins, Gary; Leveno, K.; Rosenfeld, C. R.; Porter, J. C.; MacDonald, P. C.

In: American Journal of Obstetrics and Gynecology, Vol. 160, No. 3, 1989, p. 657-662.

Research output: Contribution to journalArticle

Parker, CR, Hauth, JC, Hankins, G, Leveno, K, Rosenfeld, CR, Porter, JC & MacDonald, PC 1989, 'Endocrine maturation and lung function in premature neonates of women with diabetes', American Journal of Obstetrics and Gynecology, vol. 160, no. 3, pp. 657-662.
Parker CR, Hauth JC, Hankins G, Leveno K, Rosenfeld CR, Porter JC et al. Endocrine maturation and lung function in premature neonates of women with diabetes. American Journal of Obstetrics and Gynecology. 1989;160(3):657-662.
Parker, C. R. ; Hauth, J. C. ; Hankins, Gary ; Leveno, K. ; Rosenfeld, C. R. ; Porter, J. C. ; MacDonald, P. C. / Endocrine maturation and lung function in premature neonates of women with diabetes. In: American Journal of Obstetrics and Gynecology. 1989 ; Vol. 160, No. 3. pp. 657-662.
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