Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1

Keyphrases

• Human DNA 100%
• 5-hydroxymethylcytosine (5hmC) 100%
• DNA Methyltransferase 1 (DNMT1) 100%
• Cytosine 100%
• Methyltransferase 100%
• DNA Maintenance 100%
• Site-selectivity 100%
• Methylation 71%
• Methylation Pattern 57%
• DNA Damage 28%
• Inflammation 28%
• Human Tumors 28%
• DNA Replication 14%
• Hypomethylation 14%
• High Specificity 14%
• Tumor Suppressor Gene 14%
• Biological Effects 14%
• Oxidation Damage 14%
• Methyl Groups 14%
• Endogenous DNA Damage 14%
• Tumor Formation 14%
• Heritability 14%
• Transforming Genes 14%
• Hypermethylation 14%
• Heritable Changes 14%
• Methylation Changes 14%
• Halogenated 14%

Biochemistry, Genetics and Molecular Biology

• Methylation 100%
• Methyltransferase 100%
• DNMT1 100%
• Cytosine 100%
• DNA Damage 30%
• 5-Methylcytosine 20%
• DNA Synthesis 10%
• Carcinogenesis 10%
• Oncogene 10%
• Tumor Suppressor Gene 10%
• 5-Hydroxymethylcytosine 10%
• Biological Activity 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Methyltransferase 100%
• Cytosine 100%
• DNA (Cytosine 5) Methyltransferase 1 100%
• Inflammation 28%
• 5 Methylcytosine 28%
• Malignant Neoplasm 14%
• Carcinogenesis 14%
• Tumor Suppressor Protein 14%
• Methyl Group 14%
• 5 Hydroxymethylcytosine 14%