Endogenous vasopressin and renin-angiotensin systems support blood pressure after epidural block in humans

H. Carp, Rakesh Vadhera, A. Jayaram, D. Garvey

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: Studies in experimental animals show that endogenous Arg- vasopressin (AVP) and the renin-angiotensin system support blood pressure when the sympathetic system is impaired pharmacologically or after epidural anesthesia. However, extrapolation to humans is uncertain. Therefore, we administered an AVP type V1 receptor antagonist and an angiotensin- converting enzyme inhibitor to volunteers and measured the effect on blood pressure after epidural anesthesia. Methods: Healthy volunteers in whom epidural catheters were placed were randomly assigned to receive 1.25 mg intravenous enalapril or saline placebo followed by 0.5 mg AVP type V1 antagonist β-mercapto-β,β-cyclopentamethylene-proprionyl-o-Met-Tyr-Arg- vasopressin (AVPA) or saline placebo. Finally, 2% lidocaine was injected to obtain a T2 level. Controls received intramuscular lidocaine. Results: Blood pressure did not significantly change after T-2 epidural anesthesia in subjects treated with saline placebo, AVPA or enalapril alone (n = 10, for each treatment). In contrast, combined treatment with enalapril and AVPA resulted in a 36 ± 11% decrease in blood pressure after epidural dosing (n = 6). Controls given intramuscular lidocaine, in place of the epidural did not develop hypotension after AVPA and enalapril treatment (n = 10). Conclusions: Endogenous AVP and the renin-angiotensin system play important roles in maintaining blood pressure after epidural anesthesia in healthy subjects.

Original languageEnglish (US)
Pages (from-to)1000-1007
Number of pages8
JournalAnesthesiology
Volume80
Issue number5
StatePublished - 1994
Externally publishedYes

Fingerprint

Arginine Vasopressin
Renin-Angiotensin System
Vasopressins
Enalapril
Epidural Anesthesia
Blood Pressure
Lidocaine
Placebos
Healthy Volunteers
Vasopressin Receptors
Angiotensin-Converting Enzyme Inhibitors
Hypotension
Volunteers
Therapeutics
Catheters
1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-vasopressin
Antidiuretic Hormone Receptor Antagonists

Keywords

  • Anesthetic techniques: epidural
  • Blood pressure
  • Hormones: renin; vasopressin

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Endogenous vasopressin and renin-angiotensin systems support blood pressure after epidural block in humans. / Carp, H.; Vadhera, Rakesh; Jayaram, A.; Garvey, D.

In: Anesthesiology, Vol. 80, No. 5, 1994, p. 1000-1007.

Research output: Contribution to journalArticle

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abstract = "Background: Studies in experimental animals show that endogenous Arg- vasopressin (AVP) and the renin-angiotensin system support blood pressure when the sympathetic system is impaired pharmacologically or after epidural anesthesia. However, extrapolation to humans is uncertain. Therefore, we administered an AVP type V1 receptor antagonist and an angiotensin- converting enzyme inhibitor to volunteers and measured the effect on blood pressure after epidural anesthesia. Methods: Healthy volunteers in whom epidural catheters were placed were randomly assigned to receive 1.25 mg intravenous enalapril or saline placebo followed by 0.5 mg AVP type V1 antagonist β-mercapto-β,β-cyclopentamethylene-proprionyl-o-Met-Tyr-Arg- vasopressin (AVPA) or saline placebo. Finally, 2{\%} lidocaine was injected to obtain a T2 level. Controls received intramuscular lidocaine. Results: Blood pressure did not significantly change after T-2 epidural anesthesia in subjects treated with saline placebo, AVPA or enalapril alone (n = 10, for each treatment). In contrast, combined treatment with enalapril and AVPA resulted in a 36 ± 11{\%} decrease in blood pressure after epidural dosing (n = 6). Controls given intramuscular lidocaine, in place of the epidural did not develop hypotension after AVPA and enalapril treatment (n = 10). Conclusions: Endogenous AVP and the renin-angiotensin system play important roles in maintaining blood pressure after epidural anesthesia in healthy subjects.",
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