Abstract
Hyperemia of the tracheobronchial area is a major sign of inhalation injury. However, this is usually a qualitative symptom, without quantitative measurement. We have developed a technique to diagnose inhalation injury and to analyze damaged areas quantitatively with laser-doppler flowmetry. In chronically instrumented sheep (N = 10), the tissue blood flow in the wall of second generation bronchi was determined with an endoscopic flowmeter probe. After baseline data had been obtained, the right lung was exposed to smoke in seven animals. Three sham-smoked animals underwent the same procedure, but without actual smoke. The bronchial blood flow was measured again 30 minutes after insufflation in both groups. Inhalation injury caused a significant increase in flow, from 35.1 ± 2.6 to 51.7 ± 2.1 ml/min · 100 gm tissue in the airway of the smoked lungs but not in the control lungs. This increase correlated with an increase in the carboxyhemoglobin level (r = 0.87). The sham-smoked animals showed no change in bronchial blood flow. A valid technique for diagnosing inhalation injury in the early phase and a quantitative analysis of injured areas has been demonstrated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 313-318 |
| Number of pages | 6 |
| Journal | Journal of Burn Care and Rehabilitation |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1991 |
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ASJC Scopus subject areas
- Rehabilitation
- Surgery
- Nursing(all)
- Health Professions(all)
- Emergency Medicine
Cite this
Endoscopic laser flowmetry : A valid method for detection and quantitative analysis of inhalation injury. / Loick, H. M.; Traber, L. D.; Hurst, C.; Herndon, David; Traber, D. L.
In: Journal of Burn Care and Rehabilitation, Vol. 12, No. 4, 1991, p. 313-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endoscopic laser flowmetry
T2 - A valid method for detection and quantitative analysis of inhalation injury
AU - Loick, H. M.
AU - Traber, L. D.
AU - Hurst, C.
AU - Herndon, David
AU - Traber, D. L.
PY - 1991
Y1 - 1991
N2 - Hyperemia of the tracheobronchial area is a major sign of inhalation injury. However, this is usually a qualitative symptom, without quantitative measurement. We have developed a technique to diagnose inhalation injury and to analyze damaged areas quantitatively with laser-doppler flowmetry. In chronically instrumented sheep (N = 10), the tissue blood flow in the wall of second generation bronchi was determined with an endoscopic flowmeter probe. After baseline data had been obtained, the right lung was exposed to smoke in seven animals. Three sham-smoked animals underwent the same procedure, but without actual smoke. The bronchial blood flow was measured again 30 minutes after insufflation in both groups. Inhalation injury caused a significant increase in flow, from 35.1 ± 2.6 to 51.7 ± 2.1 ml/min · 100 gm tissue in the airway of the smoked lungs but not in the control lungs. This increase correlated with an increase in the carboxyhemoglobin level (r = 0.87). The sham-smoked animals showed no change in bronchial blood flow. A valid technique for diagnosing inhalation injury in the early phase and a quantitative analysis of injured areas has been demonstrated.
AB - Hyperemia of the tracheobronchial area is a major sign of inhalation injury. However, this is usually a qualitative symptom, without quantitative measurement. We have developed a technique to diagnose inhalation injury and to analyze damaged areas quantitatively with laser-doppler flowmetry. In chronically instrumented sheep (N = 10), the tissue blood flow in the wall of second generation bronchi was determined with an endoscopic flowmeter probe. After baseline data had been obtained, the right lung was exposed to smoke in seven animals. Three sham-smoked animals underwent the same procedure, but without actual smoke. The bronchial blood flow was measured again 30 minutes after insufflation in both groups. Inhalation injury caused a significant increase in flow, from 35.1 ± 2.6 to 51.7 ± 2.1 ml/min · 100 gm tissue in the airway of the smoked lungs but not in the control lungs. This increase correlated with an increase in the carboxyhemoglobin level (r = 0.87). The sham-smoked animals showed no change in bronchial blood flow. A valid technique for diagnosing inhalation injury in the early phase and a quantitative analysis of injured areas has been demonstrated.
UR - http://www.scopus.com/inward/record.url?scp=0026052696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026052696&partnerID=8YFLogxK
U2 - 10.1097/00004630-199107000-00006
DO - 10.1097/00004630-199107000-00006
M3 - Article
C2 - 1939302
AN - SCOPUS:0026052696
VL - 12
SP - 313
EP - 318
JO - Journal of Burn Care and Research
JF - Journal of Burn Care and Research
SN - 1559-047X
IS - 4
ER -