Endoscopic treatment of biliary leakage with n-butyl-2 cyanoacrylate

Stefan Seewald, Stefan Groth, Parupudi V.J. Sriram, He Xikun, Thawatchai Akaraviputh, Gerardo Mendoza, Boris Brand, Uwe Seitz, Frank Thonke, Nib Soehendra

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Background: Biliary leakage is a problematic complication of hepatobiliary surgery. A novel alternative method is described that can obviate the need for reoperation for refractory biliary fistula. Methods: Nine patients with large biliary leaks unresponsive to endoscopic drainage underwent N-butyl-2-cyanoacrylate glue occlusion at ERCP. Results: In 7 patients, occlusion was successful with prompt control of the fistula in a single session, averting reoperation. In 1 patient there was a partial response and in another the treatment was unsuccessful. No procedure-related complication occurred over a median follow-up of 35 months (range: 1.6-160 months). Conclusion: N-butyl-2-cyanoacrylate glue occlusion is a safe and effective endoscopic method for control of refractory bile leaks that eliminates the need for surgical reintervention.

Original languageEnglish (US)
Pages (from-to)916-919
Number of pages4
JournalGastrointestinal endoscopy
Issue number6
StatePublished - Dec 2002
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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