Endosonography-guided, fine-needle aspiration cytology extending the indication for organ-preserving pancreatic surgery

Annette Fritscher-Ravens, Jakob R. Izbicki, Sreeram Parupudi, Christina Krause, W. Trudo Knoefel, Theodoros Topalidis, Stefan Jaeckle, Frank Thonke, Nib Soehendra

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

OBJECTIVE: Organ preserving pancreatic resections are considered whenever malignant disease is ruled out. In tumors of low malignant potential such as cystadenomas and neuroendocrine tumors, the diagnosis is rarely established preoperatively. We studied the feasibility of cytodiagnosis using endosonography-guided fine-needle aspiration in determining the operative approach. METHODS: A total of 78 patients (16 female, 62 male; mean age 61.4 yr, range 31-82 yr) with focal pancreatic lesions underwent EUS-FNA. Final diagnosis was confirmed by histology, cytology, or clinical follow up (> 9 months). Patients with tumors of low malignant potential were managed by customized pancreatic resections. RESULTS: Final diagnosis was malignant tumors in 36 patients, tumors of low malignant potential in nine (six, neuroendocrine, two, borderline mucinous cystadenomas, one, borderline adenocarcinoma), and benign in 31 (two inadequate smears). No complications occurred. With six false-negative and no false-positive results, the accuracy, sensitivity, specificity, and positive and negative predictive values were 92%, 84%, 100%, 100%, and 86%, respectively. Five patients with low malignant tumors underwent duodenum-preserving pancreatic head resection, three mid segment resection, and one pylorus-preserving pancreatoduodenectomy. CONCLUSIONS: EUS-FNA is useful in the preoperative cytodiagnosis of pancreatic tumors of low malignant potential. It extends the indication for organ-preserving pancreatic resections and avoids the unnecessary sacrifice of adjacent organs. (C) 2000 by Am. Coll. of Gastroenterology.

Original languageEnglish (US)
Pages (from-to)2255-2260
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume95
Issue number9
DOIs
StatePublished - 2000
Externally publishedYes

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Endosonography
Fine Needle Biopsy
Cell Biology
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Cytodiagnosis
Neoplasms
Mucinous Cystadenoma
Cystadenoma
Pancreaticoduodenectomy
Neuroendocrine Tumors
Pylorus
Gastroenterology
Duodenum
Histology
Adenocarcinoma
Sensitivity and Specificity

ASJC Scopus subject areas

  • Gastroenterology

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Endosonography-guided, fine-needle aspiration cytology extending the indication for organ-preserving pancreatic surgery. / Fritscher-Ravens, Annette; Izbicki, Jakob R.; Parupudi, Sreeram; Krause, Christina; Knoefel, W. Trudo; Topalidis, Theodoros; Jaeckle, Stefan; Thonke, Frank; Soehendra, Nib.

In: American Journal of Gastroenterology, Vol. 95, No. 9, 2000, p. 2255-2260.

Research output: Contribution to journalArticle

Fritscher-Ravens, A, Izbicki, JR, Parupudi, S, Krause, C, Knoefel, WT, Topalidis, T, Jaeckle, S, Thonke, F & Soehendra, N 2000, 'Endosonography-guided, fine-needle aspiration cytology extending the indication for organ-preserving pancreatic surgery', American Journal of Gastroenterology, vol. 95, no. 9, pp. 2255-2260. https://doi.org/10.1016/S0002-9270(00)01103-5
Fritscher-Ravens, Annette ; Izbicki, Jakob R. ; Parupudi, Sreeram ; Krause, Christina ; Knoefel, W. Trudo ; Topalidis, Theodoros ; Jaeckle, Stefan ; Thonke, Frank ; Soehendra, Nib. / Endosonography-guided, fine-needle aspiration cytology extending the indication for organ-preserving pancreatic surgery. In: American Journal of Gastroenterology. 2000 ; Vol. 95, No. 9. pp. 2255-2260.
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abstract = "OBJECTIVE: Organ preserving pancreatic resections are considered whenever malignant disease is ruled out. In tumors of low malignant potential such as cystadenomas and neuroendocrine tumors, the diagnosis is rarely established preoperatively. We studied the feasibility of cytodiagnosis using endosonography-guided fine-needle aspiration in determining the operative approach. METHODS: A total of 78 patients (16 female, 62 male; mean age 61.4 yr, range 31-82 yr) with focal pancreatic lesions underwent EUS-FNA. Final diagnosis was confirmed by histology, cytology, or clinical follow up (> 9 months). Patients with tumors of low malignant potential were managed by customized pancreatic resections. RESULTS: Final diagnosis was malignant tumors in 36 patients, tumors of low malignant potential in nine (six, neuroendocrine, two, borderline mucinous cystadenomas, one, borderline adenocarcinoma), and benign in 31 (two inadequate smears). No complications occurred. With six false-negative and no false-positive results, the accuracy, sensitivity, specificity, and positive and negative predictive values were 92{\%}, 84{\%}, 100{\%}, 100{\%}, and 86{\%}, respectively. Five patients with low malignant tumors underwent duodenum-preserving pancreatic head resection, three mid segment resection, and one pylorus-preserving pancreatoduodenectomy. CONCLUSIONS: EUS-FNA is useful in the preoperative cytodiagnosis of pancreatic tumors of low malignant potential. It extends the indication for organ-preserving pancreatic resections and avoids the unnecessary sacrifice of adjacent organs. (C) 2000 by Am. Coll. of Gastroenterology.",
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AU - Fritscher-Ravens, Annette

AU - Izbicki, Jakob R.

AU - Parupudi, Sreeram

AU - Krause, Christina

AU - Knoefel, W. Trudo

AU - Topalidis, Theodoros

AU - Jaeckle, Stefan

AU - Thonke, Frank

AU - Soehendra, Nib

PY - 2000

Y1 - 2000

N2 - OBJECTIVE: Organ preserving pancreatic resections are considered whenever malignant disease is ruled out. In tumors of low malignant potential such as cystadenomas and neuroendocrine tumors, the diagnosis is rarely established preoperatively. We studied the feasibility of cytodiagnosis using endosonography-guided fine-needle aspiration in determining the operative approach. METHODS: A total of 78 patients (16 female, 62 male; mean age 61.4 yr, range 31-82 yr) with focal pancreatic lesions underwent EUS-FNA. Final diagnosis was confirmed by histology, cytology, or clinical follow up (> 9 months). Patients with tumors of low malignant potential were managed by customized pancreatic resections. RESULTS: Final diagnosis was malignant tumors in 36 patients, tumors of low malignant potential in nine (six, neuroendocrine, two, borderline mucinous cystadenomas, one, borderline adenocarcinoma), and benign in 31 (two inadequate smears). No complications occurred. With six false-negative and no false-positive results, the accuracy, sensitivity, specificity, and positive and negative predictive values were 92%, 84%, 100%, 100%, and 86%, respectively. Five patients with low malignant tumors underwent duodenum-preserving pancreatic head resection, three mid segment resection, and one pylorus-preserving pancreatoduodenectomy. CONCLUSIONS: EUS-FNA is useful in the preoperative cytodiagnosis of pancreatic tumors of low malignant potential. It extends the indication for organ-preserving pancreatic resections and avoids the unnecessary sacrifice of adjacent organs. (C) 2000 by Am. Coll. of Gastroenterology.

AB - OBJECTIVE: Organ preserving pancreatic resections are considered whenever malignant disease is ruled out. In tumors of low malignant potential such as cystadenomas and neuroendocrine tumors, the diagnosis is rarely established preoperatively. We studied the feasibility of cytodiagnosis using endosonography-guided fine-needle aspiration in determining the operative approach. METHODS: A total of 78 patients (16 female, 62 male; mean age 61.4 yr, range 31-82 yr) with focal pancreatic lesions underwent EUS-FNA. Final diagnosis was confirmed by histology, cytology, or clinical follow up (> 9 months). Patients with tumors of low malignant potential were managed by customized pancreatic resections. RESULTS: Final diagnosis was malignant tumors in 36 patients, tumors of low malignant potential in nine (six, neuroendocrine, two, borderline mucinous cystadenomas, one, borderline adenocarcinoma), and benign in 31 (two inadequate smears). No complications occurred. With six false-negative and no false-positive results, the accuracy, sensitivity, specificity, and positive and negative predictive values were 92%, 84%, 100%, 100%, and 86%, respectively. Five patients with low malignant tumors underwent duodenum-preserving pancreatic head resection, three mid segment resection, and one pylorus-preserving pancreatoduodenectomy. CONCLUSIONS: EUS-FNA is useful in the preoperative cytodiagnosis of pancreatic tumors of low malignant potential. It extends the indication for organ-preserving pancreatic resections and avoids the unnecessary sacrifice of adjacent organs. (C) 2000 by Am. Coll. of Gastroenterology.

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