Endothelial cell infection and hemostasis

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

As an important component of the vasculature, endothelial cell lining covers the inner surface of blood vessels and provides an active barrier interface between the vascular and perivascular compartments. In addition to maintaining vasomotor equilibrium and organ homeostasis and communicating with circulating blood cells, the vascular endothelium also serves as the preferred target for a number of infectious agents. This review article focuses on the roles of interactions between vascular endothelial cells and invading pathogens and resultant endothelial activation in the pathogenesis of important human diseases with viral and bacterial etiologies. In this perspective, the signal transduction events that regulate vascular inflammation and basis for endothelial cell tropism exhibited by certain specific viruses and pathogenic bacteria are also discussed.

Original languageEnglish (US)
Pages (from-to)531-549
Number of pages19
JournalThrombosis Research
Volume119
Issue number5
DOIs
StatePublished - Feb 28 2007
Externally publishedYes

Keywords

  • Bacteria
  • Infection
  • Pathogenesis
  • Signal transduction
  • Vascular endothelium
  • Virus

ASJC Scopus subject areas

  • Hematology

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