Endothelial cell infection and hemostasis

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

As an important component of the vasculature, endothelial cell lining covers the inner surface of blood vessels and provides an active barrier interface between the vascular and perivascular compartments. In addition to maintaining vasomotor equilibrium and organ homeostasis and communicating with circulating blood cells, the vascular endothelium also serves as the preferred target for a number of infectious agents. This review article focuses on the roles of interactions between vascular endothelial cells and invading pathogens and resultant endothelial activation in the pathogenesis of important human diseases with viral and bacterial etiologies. In this perspective, the signal transduction events that regulate vascular inflammation and basis for endothelial cell tropism exhibited by certain specific viruses and pathogenic bacteria are also discussed.

Original languageEnglish (US)
Pages (from-to)531-549
Number of pages19
JournalThrombosis Research
Volume119
Issue number5
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Hemostasis
Blood Vessels
Endothelial Cells
Infection
Tropism
Vascular Endothelium
Virus Diseases
Signal Transduction
Blood Cells
Homeostasis
Viruses
Inflammation
Bacteria

Keywords

  • Bacteria
  • Infection
  • Pathogenesis
  • Signal transduction
  • Vascular endothelium
  • Virus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

Endothelial cell infection and hemostasis. / Sahni, Sanjeev.

In: Thrombosis Research, Vol. 119, No. 5, 2007, p. 531-549.

Research output: Contribution to journalArticle

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