Abstract
As an important component of the vasculature, endothelial cell lining covers the inner surface of blood vessels and provides an active barrier interface between the vascular and perivascular compartments. In addition to maintaining vasomotor equilibrium and organ homeostasis and communicating with circulating blood cells, the vascular endothelium also serves as the preferred target for a number of infectious agents. This review article focuses on the roles of interactions between vascular endothelial cells and invading pathogens and resultant endothelial activation in the pathogenesis of important human diseases with viral and bacterial etiologies. In this perspective, the signal transduction events that regulate vascular inflammation and basis for endothelial cell tropism exhibited by certain specific viruses and pathogenic bacteria are also discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 531-549 |
| Number of pages | 19 |
| Journal | Thrombosis Research |
| Volume | 119 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2007 |
| Externally published | Yes |
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Keywords
- Bacteria
- Infection
- Pathogenesis
- Signal transduction
- Vascular endothelium
- Virus
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Hematology
Cite this
Endothelial cell infection and hemostasis. / Sahni, Sanjeev.
In: Thrombosis Research, Vol. 119, No. 5, 2007, p. 531-549.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endothelial cell infection and hemostasis
AU - Sahni, Sanjeev
PY - 2007
Y1 - 2007
N2 - As an important component of the vasculature, endothelial cell lining covers the inner surface of blood vessels and provides an active barrier interface between the vascular and perivascular compartments. In addition to maintaining vasomotor equilibrium and organ homeostasis and communicating with circulating blood cells, the vascular endothelium also serves as the preferred target for a number of infectious agents. This review article focuses on the roles of interactions between vascular endothelial cells and invading pathogens and resultant endothelial activation in the pathogenesis of important human diseases with viral and bacterial etiologies. In this perspective, the signal transduction events that regulate vascular inflammation and basis for endothelial cell tropism exhibited by certain specific viruses and pathogenic bacteria are also discussed.
AB - As an important component of the vasculature, endothelial cell lining covers the inner surface of blood vessels and provides an active barrier interface between the vascular and perivascular compartments. In addition to maintaining vasomotor equilibrium and organ homeostasis and communicating with circulating blood cells, the vascular endothelium also serves as the preferred target for a number of infectious agents. This review article focuses on the roles of interactions between vascular endothelial cells and invading pathogens and resultant endothelial activation in the pathogenesis of important human diseases with viral and bacterial etiologies. In this perspective, the signal transduction events that regulate vascular inflammation and basis for endothelial cell tropism exhibited by certain specific viruses and pathogenic bacteria are also discussed.
KW - Bacteria
KW - Infection
KW - Pathogenesis
KW - Signal transduction
KW - Vascular endothelium
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=33847216826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847216826&partnerID=8YFLogxK
U2 - 10.1016/j.thromres.2006.06.006
DO - 10.1016/j.thromres.2006.06.006
M3 - Article
C2 - 16875715
AN - SCOPUS:33847216826
VL - 119
SP - 531
EP - 549
JO - Thrombosis Research
JF - Thrombosis Research
SN - 0049-3848
IS - 5
ER -