Endothelial function and the regulation of muscle protein anabolism in older adults

K. L. Timmerman, Elena Volpi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Sarcopenia, the loss of skeletal muscle mass and function with aging, is a major contributor to frailty and morbidity in older adults. Recent evidence has emerged suggesting that endothelial dysfunction and insulin resistance of muscle protein metabolism may significantly contribute to the development of sarcopenia. In this article we review: 1) recent studies and theories on the regulation of skeletal muscle protein balance in older adults; 2) the linkbetween insulin resistance of muscle protein synthesis and endothelial dysfunction in aging; 3) mechanisms for impaired endothelial responsiveness in aging; and 4) potential treatments that may restore the endothelial responsiveness and muscle protein anabolic sensitivity in older adults.

Original languageEnglish (US)
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume23
Issue numberSUPPL1
DOIs
StatePublished - 2013

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Muscle Proteins
Sarcopenia
Insulin Resistance
Skeletal Muscle
Morbidity

Keywords

  • Endothelial dysfunction
  • Insulin resistance
  • Muscle protein metabolism
  • Sarcopenia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Endothelial function and the regulation of muscle protein anabolism in older adults. / Timmerman, K. L.; Volpi, Elena.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 23, No. SUPPL1, 2013.

Research output: Contribution to journalArticle

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