Endovascular image-guided treatment of in-vivo model aneurysms with asymmetric vascular stents (AVS): Evaluation with time-density curve angiographic analysis and histology

A. Dohatcu, C. N. Ionita, A. Paciorek, D. R. Bednarek, K. R. Hoffmann, S. Rudin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

In this study, we compare the results obtained from Time-Density Curve (TDC) analysis of angiographic imaging sequences with histological evaluation for a rabbit aneurysm model treated with standard stents and new asymmetric vascular stents (AVS) placed by image-guided endovascular deployment. AVSs are stents having a low-porosity patch region designed to cover the aneurysm neck and occlude blood flow inside. To evaluate the AVSs, rabbits with elastase-induced aneurysm models (n=20) were divided into three groups: the first (n=10) was treated with an AVS, the second (n=5) with a non-patch standard coronary stent, and third was untreated as a control (n=5). We used TDC analysis to measure how much contrast media entered the aneurysm before and after treatment. TDCs track contrast-media-density changes as a function of time over the region of interest in x-ray DSA cine-sequences. After 28 days, the animals were sacrificed and the explanted specimens were histologically evaluated. The first group showed an average reduction of contrast flow into the aneurysm of 95% after treatment with an AVS with fully developed thrombus at 28 days follow-up. The rabbits treated with standard stents showed an increase in TDC residency time after treatment and partial-thrombogenesis. The untreated control aneurysms displayed no reduction in flow and were still patent at follow-up. The quantitative TDC analysis findings were confirmed by histological evaluation suggesting that the new AVS has great potential as a definitive treatment for cerebro-vascular aneurysms and that angiographic TDC analysis can provide in-vivo verification.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images
Volume6916
DOIs
StatePublished - 2008
Externally publishedYes
EventMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 17 2008Feb 19 2008

Other

OtherMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images
Country/TerritoryUnited States
CitySan Diego, CA
Period2/17/082/19/08

Keywords

  • Angiographic time-density curves
  • Asymmetric vascular stent
  • Elastase rabbit model
  • Histology

ASJC Scopus subject areas

  • Engineering(all)

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