Endovascular image-guided treatment of in-vivo model aneurysms with asymmetric vascular stents (AVS): Evaluation with time-density curve angiographic analysis and histology

A. Dohatcu, C. N. Ionita, A. Paciorek, D. R. Bednarek, K. R. Hoffmann, S. Rudin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)

Abstract

In this study, we compare the results obtained from Time-Density Curve (TDC) analysis of angiographic imaging sequences with histological evaluation for a rabbit aneurysm model treated with standard stents and new asymmetric vascular stents (AVS) placed by image-guided endovascular deployment. AVSs are stents having a low-porosity patch region designed to cover the aneurysm neck and occlude blood flow inside. To evaluate the AVSs, rabbits with elastase-induced aneurysm models (n=20) were divided into three groups: the first (n=10) was treated with an AVS, the second (n=5) with a non-patch standard coronary stent, and third was untreated as a control (n=5). We used TDC analysis to measure how much contrast media entered the aneurysm before and after treatment. TDCs track contrast-media-density changes as a function of time over the region of interest in x-ray DSA cine-sequences. After 28 days, the animals were sacrificed and the explanted specimens were histologically evaluated. The first group showed an average reduction of contrast flow into the aneurysm of 95% after treatment with an AVS with fully developed thrombus at 28 days follow-up. The rabbits treated with standard stents showed an increase in TDC residency time after treatment and partial-thrombogenesis. The untreated control aneurysms displayed no reduction in flow and were still patent at follow-up. The quantitative TDC analysis findings were confirmed by histological evaluation suggesting that the new AVS has great potential as a definitive treatment for cerebro-vascular aneurysms and that angiographic TDC analysis can provide in-vivo verification.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images
Volume6916
DOIs
StatePublished - 2008
Externally publishedYes
EventMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 17 2008Feb 19 2008

Other

OtherMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period2/17/082/19/08

Fingerprint

Histology
Stents
Contrast media
Animals
Blood
Porosity
Imaging techniques
X rays

Keywords

  • Angiographic time-density curves
  • Asymmetric vascular stent
  • Elastase rabbit model
  • Histology

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Dohatcu, A., Ionita, C. N., Paciorek, A., Bednarek, D. R., Hoffmann, K. R., & Rudin, S. (2008). Endovascular image-guided treatment of in-vivo model aneurysms with asymmetric vascular stents (AVS): Evaluation with time-density curve angiographic analysis and histology. In Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images (Vol. 6916). [69160P] https://doi.org/10.1117/12.769504

Endovascular image-guided treatment of in-vivo model aneurysms with asymmetric vascular stents (AVS) : Evaluation with time-density curve angiographic analysis and histology. / Dohatcu, A.; Ionita, C. N.; Paciorek, A.; Bednarek, D. R.; Hoffmann, K. R.; Rudin, S.

Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images. Vol. 6916 2008. 69160P.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dohatcu, A, Ionita, CN, Paciorek, A, Bednarek, DR, Hoffmann, KR & Rudin, S 2008, Endovascular image-guided treatment of in-vivo model aneurysms with asymmetric vascular stents (AVS): Evaluation with time-density curve angiographic analysis and histology. in Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images. vol. 6916, 69160P, Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images, San Diego, CA, United States, 2/17/08. https://doi.org/10.1117/12.769504
Dohatcu A, Ionita CN, Paciorek A, Bednarek DR, Hoffmann KR, Rudin S. Endovascular image-guided treatment of in-vivo model aneurysms with asymmetric vascular stents (AVS): Evaluation with time-density curve angiographic analysis and histology. In Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images. Vol. 6916. 2008. 69160P https://doi.org/10.1117/12.769504
Dohatcu, A. ; Ionita, C. N. ; Paciorek, A. ; Bednarek, D. R. ; Hoffmann, K. R. ; Rudin, S. / Endovascular image-guided treatment of in-vivo model aneurysms with asymmetric vascular stents (AVS) : Evaluation with time-density curve angiographic analysis and histology. Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images. Vol. 6916 2008.
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