Enhanced immunoglobulin A release from human colostral cells during phagocytosis

E. A. Weaver, R. M. Goldblum, C. P. Davis, A. S. Goldman

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Human colostral leukocytes were investigated for their ability to release immunoglobulin A during phagocytosis of latex particles, heat-killed Candida albicans, or live Escherichia coli. Leukocytes readily phagocytosed latex or serum-opsonized Candida or the E. coli. Colostral fluid was also opsonic for yeast and bacteria. Immunoglobulin release, which consisted mainly of secretory immunoglobulin A, began during the first 15 min of incubation with latex, opsonized yeast, or opsonized bacteria. Release was significantly increased from control levels by 30 or 60 min. The release of immunoglobulin A could be inhibited by incubating leukocytes at 4° C. We conclude that phagocytosis and immunoglobulin A release by human colostral leukocytes are related. The data support the hypothesis that colostral leukocytes may play an active role in protecting infants from pathogenic microorganisms.

Original languageEnglish (US)
Pages (from-to)498-502
Number of pages5
JournalInfection and Immunity
Volume34
Issue number2
StatePublished - 1981

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Cytophagocytosis
Immunoglobulin A
Leukocytes
Phagocytosis
Latex
Yeasts
Escherichia coli
Bacteria
Secretory Immunoglobulin A
Candida albicans
Microspheres
Candida
Immunoglobulins
Hot Temperature
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Weaver, E. A., Goldblum, R. M., Davis, C. P., & Goldman, A. S. (1981). Enhanced immunoglobulin A release from human colostral cells during phagocytosis. Infection and Immunity, 34(2), 498-502.

Enhanced immunoglobulin A release from human colostral cells during phagocytosis. / Weaver, E. A.; Goldblum, R. M.; Davis, C. P.; Goldman, A. S.

In: Infection and Immunity, Vol. 34, No. 2, 1981, p. 498-502.

Research output: Contribution to journalArticle

Weaver, EA, Goldblum, RM, Davis, CP & Goldman, AS 1981, 'Enhanced immunoglobulin A release from human colostral cells during phagocytosis', Infection and Immunity, vol. 34, no. 2, pp. 498-502.
Weaver EA, Goldblum RM, Davis CP, Goldman AS. Enhanced immunoglobulin A release from human colostral cells during phagocytosis. Infection and Immunity. 1981;34(2):498-502.
Weaver, E. A. ; Goldblum, R. M. ; Davis, C. P. ; Goldman, A. S. / Enhanced immunoglobulin A release from human colostral cells during phagocytosis. In: Infection and Immunity. 1981 ; Vol. 34, No. 2. pp. 498-502.
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