Enhanced myocardial function in transgenic mice overexpressing the β2-adrenergic receptor

C. A. Milano, L. F. Allen, H. A. Rockman, P. C. Dolber, T. R. McMinn, K. R. Chien, T. D. Johnson, R. A. Bond, R. J. Lefkowitz

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    Abstract

    Transgenic mice were created with cardiac-specific overexpression of the β2-adrenergic receptor. This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol. These results illustrate a useful approach for studying the effect of gene expression on cardiac contractility. Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial β-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state.

    Original languageEnglish (US)
    Pages (from-to)582-586
    Number of pages5
    JournalScience
    Volume264
    Issue number5158
    DOIs
    StatePublished - Jan 1 1994

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    Cite this

    Milano, C. A., Allen, L. F., Rockman, H. A., Dolber, P. C., McMinn, T. R., Chien, K. R., Johnson, T. D., Bond, R. A., & Lefkowitz, R. J. (1994). Enhanced myocardial function in transgenic mice overexpressing the β2-adrenergic receptor. Science, 264(5158), 582-586. https://doi.org/10.1126/science.8160017