Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef

A. H. Conney, E. J. Pantuck, K. C. Hsiao, W. A. Garlan, K. E. Anderson, A. P. Alvares, A. Kappas

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

There were marked individual differences in the plasma levels of phenacetin after oral administration of a 900-mg dose to 9 normal volunteers eating their customary home diet. Feeding a diet that contained charcoal-broiled beef for 4 days prior to the administration of phenacetin markedly decreased the plasma levels of this drug without appreciably influencing the plasma concentrations of phenacetin's metabolite, N-acetyl-p-aminophenol (APAP), or the plasma half-life of phenacetin. The average peak concentration of phenacetin in plasma, after a 900-mg oral dose, fell from 1,628 ng/ml, when the subjects were fed a control diet for 7 days, to 352 nglml after they were fed the same diet which contained charcoal-broiled beef for 4 days. The average peak concentration of phenacetin rose to 1,885 nglml after the subjects were subsequently fed the control diet for 7 days. The ratios of the average concentrations of APAP in plasma to those of phenacetin markedly increased after the charcoal-broiled beef diet. The results suggest that a diet containing charcoal-broiled beef enhances the metabolism of phenacetin in the gastrointestinal tract and/or during its first pass through the liver. This effect greatly decreases the bioavailability of phenacetin.

Original languageEnglish (US)
Pages (from-to)633-642
Number of pages10
JournalClinical Pharmacology and Therapeutics
Volume20
Issue number6
DOIs
StatePublished - Dec 1976
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Conney, A. H., Pantuck, E. J., Hsiao, K. C., Garlan, W. A., Anderson, K. E., Alvares, A. P., & Kappas, A. (1976). Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clinical Pharmacology and Therapeutics, 20(6), 633-642. https://doi.org/10.1002/cpt1976206633