Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef

A. H. Conney, E. J. Pantuck, K. C. Hsiao, W. A. Garlan, Karl Anderson, A. P. Alvares, A. Kappas

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

There were marked individual differences in the plasma levels of phenacetin after oral administration of a 900-mg dose to 9 normal volunteers eating their customary home diet. Feeding a diet that contained charcoal-broiled beef for 4 days prior to the administration of phenacetin markedly decreased the plasma levels of this drug without appreciably influencing the plasma concentrations of phenacetin's metabolite, N-acetyl-p-aminophenol (APAP), or the plasma half-life of phenacetin. The average peak concentration of phenacetin in plasma, after a 900-mg oral dose, fell from 1,628 ng/ml, when the subjects were fed a control diet for 7 days, to 352 nglml after they were fed the same diet which contained charcoal-broiled beef for 4 days. The average peak concentration of phenacetin rose to 1,885 nglml after the subjects were subsequently fed the control diet for 7 days. The ratios of the average concentrations of APAP in plasma to those of phenacetin markedly increased after the charcoal-broiled beef diet. The results suggest that a diet containing charcoal-broiled beef enhances the metabolism of phenacetin in the gastrointestinal tract and/or during its first pass through the liver. This effect greatly decreases the bioavailability of phenacetin.

Original languageEnglish (US)
Pages (from-to)633-642
Number of pages10
JournalClinical Pharmacology and Therapeutics
Volume20
Issue number6
StatePublished - Dec 1976
Externally publishedYes

Fingerprint

Phenacetin
Charcoal
Diet
Acetaminophen
Red Meat
Individuality
Biological Availability
Oral Administration
Half-Life
Gastrointestinal Tract
Healthy Volunteers
Eating

ASJC Scopus subject areas

  • Pharmacology

Cite this

Conney, A. H., Pantuck, E. J., Hsiao, K. C., Garlan, W. A., Anderson, K., Alvares, A. P., & Kappas, A. (1976). Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clinical Pharmacology and Therapeutics, 20(6), 633-642.

Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. / Conney, A. H.; Pantuck, E. J.; Hsiao, K. C.; Garlan, W. A.; Anderson, Karl; Alvares, A. P.; Kappas, A.

In: Clinical Pharmacology and Therapeutics, Vol. 20, No. 6, 12.1976, p. 633-642.

Research output: Contribution to journalArticle

Conney, AH, Pantuck, EJ, Hsiao, KC, Garlan, WA, Anderson, K, Alvares, AP & Kappas, A 1976, 'Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef', Clinical Pharmacology and Therapeutics, vol. 20, no. 6, pp. 633-642.
Conney AH, Pantuck EJ, Hsiao KC, Garlan WA, Anderson K, Alvares AP et al. Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clinical Pharmacology and Therapeutics. 1976 Dec;20(6):633-642.
Conney, A. H. ; Pantuck, E. J. ; Hsiao, K. C. ; Garlan, W. A. ; Anderson, Karl ; Alvares, A. P. ; Kappas, A. / Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. In: Clinical Pharmacology and Therapeutics. 1976 ; Vol. 20, No. 6. pp. 633-642.
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