Enhanced reactive oxygen species metabolism of airspace cells and airway inflammation follow antigen challenge in human asthma

William Calhoun, Robert K. Bush, Steven M. Salisbury, Carol A. Stevens

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Airflow limitation and airway inflammation follow antigen bronchoprovocation in sensitized individuals. Inflammation likely results from the interplay of several previously demonstrated factors, but the participation and persistance of enhanced reactive oxygen species (ROS) metabolism of airspace cells after antigen challenge have received more limited attention. We studied nine subjects with mild asthma by bronchoalveolar lavage before and 48 (one subject) to 72 (eight subjects) hours after antigen bronchoprovocation and compared airspace cell numbers and types, cell function, and bronchoalveolar lavage fluid protein, albumin, and immunoglobulins. Mild, but significant, airflow limitation persisted at the time of the second lavage. Eosinophil influx was a notable component of the increased airspace cells in postchallenge lavages. Airspace cells demonstrated significantly enhanced ROS metabolism, and total protein, albumin, and IgM levels were higher in postchallenge lavage specimens. Antigen bronchial challenge produces airspace inflammation, which may develop, in part, as a consequence of enhanced ROS metabolism of airspace cells.

Original languageEnglish (US)
Pages (from-to)306-313
Number of pages8
JournalThe Journal of Allergy and Clinical Immunology
Volume86
Issue number3 PART 1
DOIs
StatePublished - 1990
Externally publishedYes

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Reactive Oxygen Species
Asthma
Inflammation
Therapeutic Irrigation
Antigens
Albumins
Bronchoalveolar Lavage Fluid
Bronchoalveolar Lavage
Eosinophils
Immunoglobulin M
Immunoglobulins
Proteins
Cell Count

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Enhanced reactive oxygen species metabolism of airspace cells and airway inflammation follow antigen challenge in human asthma. / Calhoun, William; Bush, Robert K.; Salisbury, Steven M.; Stevens, Carol A.

In: The Journal of Allergy and Clinical Immunology, Vol. 86, No. 3 PART 1, 1990, p. 306-313.

Research output: Contribution to journalArticle

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