Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

Fabien Aubry; Stéphanie Dabo; Caroline Manet; Igor Filipović; Noah H. Rose; Elliott F. Miot; Daria Martynow; Artem Baidaliuk; Sarah H. Merkling; Laura B. Dickson; Anna B. Crist; Victor O. Anyango; Claudia M. Romero-Vivas; Anubis Vega-Rúa; Isabelle Dusfour; Davy Jiolle; Christophe Paupy; Martin N. Mayanja; Julius J. Lutwama; Alain Kohl; Veasna Duong; Alongkot Ponlawat; Massamba Sylla; Jewelna Akorli; Sampson Otoo; Joel Lutomiah; Rosemary Sang; John Paul Mutebi; Van Mai Cao-Lormeau; Richard G. Jarman; Cheikh T. Diagne; Oumar Faye; Ousmane Faye; Amadou A. Sall; Carolyn S. McBride; Xavier Montagutelli; Gordana Rašić; Louis Lambrechts

doi:10.1126/science.abd3663

Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

Fabien Aubry, Stéphanie Dabo, Caroline Manet, Igor Filipović, Noah H. Rose, Elliott F. Miot, Daria Martynow, Artem Baidaliuk, Sarah H. Merkling, Laura B. Dickson, Anna B. Crist, Victor O. Anyango, Claudia M. Romero-Vivas, Anubis Vega-Rúa, Isabelle Dusfour, Davy Jiolle, Christophe Paupy, Martin N. Mayanja, Julius J. Lutwama, Alain KohlVeasna Duong, Alongkot Ponlawat, Massamba Sylla, Jewelna Akorli, Sampson Otoo, Joel Lutomiah, Rosemary Sang, John Paul Mutebi, Van Mai Cao-Lormeau, Richard G. Jarman, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Carolyn S. McBride, Xavier Montagutelli, Gordana Rašić, Louis Lambrechts

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most of the world’s tropical belt over the past four centuries, after the evolution of a “domestic” form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of A. aegypti out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of A. aegypti promoted arbovirus emergence not solely through increased vector–host contact but also as a result of enhanced vector susceptibility.

Original language	English (US)
Pages (from-to)	991-996
Number of pages	6
Journal	Science
Volume	370
Issue number	6519
DOIs	https://doi.org/10.1126/science.abd3663
State	Published - Nov 20 2020
Externally published	Yes

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Aubry, F., Dabo, S., Manet, C., Filipović, I., Rose, N. H., Miot, E. F., Martynow, D., Baidaliuk, A., Merkling, S. H., Dickson, L. B., Crist, A. B., Anyango, V. O., Romero-Vivas, C. M., Vega-Rúa, A., Dusfour, I., Jiolle, D., Paupy, C., Mayanja, M. N., Lutwama, J. J., ... Lambrechts, L. (2020). Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations. Science, 370(6519), 991-996. https://doi.org/10.1126/science.abd3663

Aubry, F, Dabo, S, Manet, C, Filipović, I, Rose, NH, Miot, EF, Martynow, D, Baidaliuk, A, Merkling, SH, Dickson, LB, Crist, AB, Anyango, VO, Romero-Vivas, CM, Vega-Rúa, A, Dusfour, I, Jiolle, D, Paupy, C, Mayanja, MN, Lutwama, JJ, Kohl, A, Duong, V, Ponlawat, A, Sylla, M, Akorli, J, Otoo, S, Lutomiah, J, Sang, R, Mutebi, JP, Cao-Lormeau, VM, Jarman, RG, Diagne, CT, Faye, O, Faye, O, Sall, AA, McBride, CS, Montagutelli, X, Rašić, G & Lambrechts, L 2020, 'Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations', Science, vol. 370, no. 6519, pp. 991-996. https://doi.org/10.1126/science.abd3663

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title = "Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations",

abstract = "The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most of the world{\textquoteright}s tropical belt over the past four centuries, after the evolution of a “domestic” form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of A. aegypti out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of A. aegypti promoted arbovirus emergence not solely through increased vector–host contact but also as a result of enhanced vector susceptibility.",

author = "Fabien Aubry and St{\'e}phanie Dabo and Caroline Manet and Igor Filipovi{\'c} and Rose, {Noah H.} and Miot, {Elliott F.} and Daria Martynow and Artem Baidaliuk and Merkling, {Sarah H.} and Dickson, {Laura B.} and Crist, {Anna B.} and Anyango, {Victor O.} and Romero-Vivas, {Claudia M.} and Anubis Vega-R{\'u}a and Isabelle Dusfour and Davy Jiolle and Christophe Paupy and Mayanja, {Martin N.} and Lutwama, {Julius J.} and Alain Kohl and Veasna Duong and Alongkot Ponlawat and Massamba Sylla and Jewelna Akorli and Sampson Otoo and Joel Lutomiah and Rosemary Sang and Mutebi, {John Paul} and Cao-Lormeau, {Van Mai} and Jarman, {Richard G.} and Diagne, {Cheikh T.} and Oumar Faye and Ousmane Faye and Sall, {Amadou A.} and McBride, {Carolyn S.} and Xavier Montagutelli and Gordana Ra{\v s}i{\'c} and Louis Lambrechts",

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AU - Dabo, Stéphanie

AU - Manet, Caroline

AU - Filipović, Igor

AU - Rose, Noah H.

AU - Miot, Elliott F.

AU - Martynow, Daria

AU - Baidaliuk, Artem

AU - Merkling, Sarah H.

AU - Dickson, Laura B.

AU - Crist, Anna B.

AU - Anyango, Victor O.

AU - Romero-Vivas, Claudia M.

AU - Vega-Rúa, Anubis

AU - Dusfour, Isabelle

AU - Jiolle, Davy

AU - Paupy, Christophe

AU - Mayanja, Martin N.

AU - Lutwama, Julius J.

AU - Kohl, Alain

AU - Duong, Veasna

AU - Ponlawat, Alongkot

AU - Sylla, Massamba

AU - Akorli, Jewelna

AU - Otoo, Sampson

AU - Lutomiah, Joel

AU - Sang, Rosemary

AU - Mutebi, John Paul

AU - Cao-Lormeau, Van Mai

AU - Jarman, Richard G.

AU - Diagne, Cheikh T.

AU - Faye, Oumar

AU - Faye, Ousmane

AU - Sall, Amadou A.

AU - McBride, Carolyn S.

AU - Montagutelli, Xavier

AU - Rašić, Gordana

AU - Lambrechts, Louis

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AB - The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most of the world’s tropical belt over the past four centuries, after the evolution of a “domestic” form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of A. aegypti out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of A. aegypti promoted arbovirus emergence not solely through increased vector–host contact but also as a result of enhanced vector susceptibility.

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Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

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