Enhancement by calcium of the invasiveness of Salmonella for HeLa cell monolayers.

Research output: Contribution to journalReview article

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Abstract

An outer membrane-associated cytotoxin and the invasive capacity of Salmonella were shown to be modulated by divalent cations. Cell detachment activity of salmonella cytotoxin was blocked by addition of either Ca++ or Mg++. It is interesting that Ca++ but not other divalent cations was shown to enhance the invasiveness of Salmonella for HeLa cell monolayers. The dose-dependent Ca++ effect required metabolism and was not simply the result of Ca++ binding to the surface of the bacteria. These data suggest a possible role of divalent cations in the unique relationship of invasive bacteria and host cells.

Original languageEnglish (US)
Pages (from-to)S319-322
JournalReviews of infectious diseases
Volume10 Suppl 2
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Microbiology (medical)

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