ENPP1/PC-1 K121Q and other predictors of posttransplant diabetes

Magdalene Szuszkiewicz, Jason Bell, Miguel Vazquez, Beverley Adams-Huet, Scott M. Grundy, Manisha Chandalia, Nicola Abate

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Diabetes mellitus is a major cause of morbidity and mortality among transplanted patients. This study evaluated the role of the ENPP1 K121Q polymorphism and other variables known to affect diabetes risk in 115 nondiabetic and unrelated patients who underwent kidney transplant at our institution and had consented for use of genetic material (30% whites, 48% blacks, and 22% Hispanics). Thirty-six of these patients (30%) developed posttransplant diabetes mellitus (PTDM) within 1 year of observation from transplant. Black race, ENPP1 K121Q polymorphism, age, body mass index (BMI), and immunosuppressive medications were found to have the strongest associations with PTDM in the logistic regression and receiver operator characteristic (ROC) analysis. However, because ENPP1 K121Q is more common in Hispanics and in blacks, who also have higher PTDM prevalence, the studied genetic polymorphism did not exert independent predictive effect, whereas ethnicity, specifically black versus non-black, was the most robust predictor of PTDM. The model with the largest ROC area under the curve (AUC) of 0.80 was comprised of black/non-black, age, BMI, and tacrolimus treatment as significant predictors. A reduced model containing only ethnicity (black/non-black) and age as predictors yielded similar results (ROC AUC 0.78). We conclude that black race and age are major and not modifiable risk factors for PTDM. The specific role of ENPP1 K121Q on ethnic susceptibility to PTDM deserves further investigation in larger cohorts of transplanted patients.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalMetabolic Syndrome and Related Disorders
Volume9
Issue number1
DOIs
StatePublished - Feb 1 2011

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Diabetes Mellitus
Hispanic Americans
Area Under Curve
Body Mass Index
Transplants
Tacrolimus
Genetic Polymorphisms
Immunosuppressive Agents
Logistic Models
Observation
Morbidity
Kidney
Mortality
Genes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Szuszkiewicz, M., Bell, J., Vazquez, M., Adams-Huet, B., Grundy, S. M., Chandalia, M., & Abate, N. (2011). ENPP1/PC-1 K121Q and other predictors of posttransplant diabetes. Metabolic Syndrome and Related Disorders, 9(1), 25-29. https://doi.org/10.1089/met.2010.0041

ENPP1/PC-1 K121Q and other predictors of posttransplant diabetes. / Szuszkiewicz, Magdalene; Bell, Jason; Vazquez, Miguel; Adams-Huet, Beverley; Grundy, Scott M.; Chandalia, Manisha; Abate, Nicola.

In: Metabolic Syndrome and Related Disorders, Vol. 9, No. 1, 01.02.2011, p. 25-29.

Research output: Contribution to journalArticle

Szuszkiewicz, M, Bell, J, Vazquez, M, Adams-Huet, B, Grundy, SM, Chandalia, M & Abate, N 2011, 'ENPP1/PC-1 K121Q and other predictors of posttransplant diabetes', Metabolic Syndrome and Related Disorders, vol. 9, no. 1, pp. 25-29. https://doi.org/10.1089/met.2010.0041
Szuszkiewicz M, Bell J, Vazquez M, Adams-Huet B, Grundy SM, Chandalia M et al. ENPP1/PC-1 K121Q and other predictors of posttransplant diabetes. Metabolic Syndrome and Related Disorders. 2011 Feb 1;9(1):25-29. https://doi.org/10.1089/met.2010.0041
Szuszkiewicz, Magdalene ; Bell, Jason ; Vazquez, Miguel ; Adams-Huet, Beverley ; Grundy, Scott M. ; Chandalia, Manisha ; Abate, Nicola. / ENPP1/PC-1 K121Q and other predictors of posttransplant diabetes. In: Metabolic Syndrome and Related Disorders. 2011 ; Vol. 9, No. 1. pp. 25-29.
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