ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes

Nicola Abate, Manisha Chandalia, Pankaj Satija, Beverley Adams-Huet, Scott M. Grundy, Sreedharan Sandeep, Venkatesan Radha, Raj Deepa, Viswanathan Mohan

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Genetic susceptibility modulates the impact of obesity on risk for type 2 diabetes. The present study evaluates the role of ENPP1 K121Q polymorphism in prediction of type 2 diabetes in three populations that differ in susceptibility to diabetes and environmental exposure. The three cohorts included 679 nonmigrant South Asians living in Chennai, India (223 with type 2 diabetes); 1,083 migrant South Asians living in Dallas, Texas (121 with type 2 diabetes); and 858 nonmigrant Caucasians living in Dallas, Texas (141 with type 2 diabetes). Patients with type 2 diabetes were included in these cohorts if they had diabetes onset before the age of 60 years. The prevalence of subjects carrying the polymorphic ENPP1 121Q allele was 25% in the nondiabetic group and 34% in the diabetic group of South Asians living in Chennai (P = 0.01). The prevalence in the nondiabetic and diabetic groups were 33 and 45% (P = 0.01) for the South Asians living in Dallas and 26 and 39% (P = 0.003) for the Caucasians. Although 'further replication studies are necessary to test the validity of the described genotype-phenotype relationship, our study supports the hypothesis that ENPP1 121Q predicts genetic susceptibility to type 2 diabetes in both South Asians and Caucasians.

Original languageEnglish (US)
Pages (from-to)1207-1213
Number of pages7
JournalDiabetes
Volume54
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

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Genetic Predisposition to Disease
Type 2 Diabetes Mellitus
Environmental Exposure
Age of Onset
India
Obesity
Alleles
Genotype
Phenotype
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Abate, N., Chandalia, M., Satija, P., Adams-Huet, B., Grundy, S. M., Sandeep, S., ... Mohan, V. (2005). ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. Diabetes, 54(4), 1207-1213. https://doi.org/10.2337/diabetes.54.4.1207

ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. / Abate, Nicola; Chandalia, Manisha; Satija, Pankaj; Adams-Huet, Beverley; Grundy, Scott M.; Sandeep, Sreedharan; Radha, Venkatesan; Deepa, Raj; Mohan, Viswanathan.

In: Diabetes, Vol. 54, No. 4, 04.2005, p. 1207-1213.

Research output: Contribution to journalArticle

Abate, N, Chandalia, M, Satija, P, Adams-Huet, B, Grundy, SM, Sandeep, S, Radha, V, Deepa, R & Mohan, V 2005, 'ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes', Diabetes, vol. 54, no. 4, pp. 1207-1213. https://doi.org/10.2337/diabetes.54.4.1207
Abate N, Chandalia M, Satija P, Adams-Huet B, Grundy SM, Sandeep S et al. ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. Diabetes. 2005 Apr;54(4):1207-1213. https://doi.org/10.2337/diabetes.54.4.1207
Abate, Nicola ; Chandalia, Manisha ; Satija, Pankaj ; Adams-Huet, Beverley ; Grundy, Scott M. ; Sandeep, Sreedharan ; Radha, Venkatesan ; Deepa, Raj ; Mohan, Viswanathan. / ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. In: Diabetes. 2005 ; Vol. 54, No. 4. pp. 1207-1213.
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