Enteropathogenic Escherichia coli: Foe or innocent bystander?

J. Hu; A. G. Torres

doi:10.1016/j.cmi.2015.01.015

Enteropathogenic Escherichia coli: Foe or innocent bystander?

J. Hu, A. G. Torres

Research output: Contribution to journal › Review article › peer-review

138 Scopus citations

Abstract

Enteropathogenic Escherichia coli (EPEC) remain one the most important pathogens infecting children and they are one of the main causes of persistent diarrhoea worldwide. Historically, typical EPEC (tEPEC), defined as those isolates with the attaching and effacement (A/E) genotype (eae⁺), which possess bfpA⁺ and lack the stx^- genes are found strongly associated with diarrhoeal cases. However, occurrence of atypical EPEC (aEPEC; eae⁺ bfpA^- stx^-) in diarrhoeal and asymptomatic hosts has made investigators question the role of these pathogens in human disease. Current epidemiological data are helping to answer the question of whether EPEC is mainly a foe or an innocent bystander during infection.

Original language	English (US)
Pages (from-to)	729-734
Number of pages	6
Journal	Clinical Microbiology and Infection
Volume	21
Issue number	8
DOIs	https://doi.org/10.1016/j.cmi.2015.01.015
State	Published - Aug 1 2015
Externally published	Yes

Keywords

Asymptomatic pathogenic escherichia coli
Atypical EPEC
Diarrhoea
Enteropathogenic escherichia coli
Epidemiology

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.cmi.2015.01.015

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title = "Enteropathogenic Escherichia coli: Foe or innocent bystander?",

abstract = "Enteropathogenic Escherichia coli (EPEC) remain one the most important pathogens infecting children and they are one of the main causes of persistent diarrhoea worldwide. Historically, typical EPEC (tEPEC), defined as those isolates with the attaching and effacement (A/E) genotype (eae+), which possess bfpA+ and lack the stx- genes are found strongly associated with diarrhoeal cases. However, occurrence of atypical EPEC (aEPEC; eae+ bfpA- stx-) in diarrhoeal and asymptomatic hosts has made investigators question the role of these pathogens in human disease. Current epidemiological data are helping to answer the question of whether EPEC is mainly a foe or an innocent bystander during infection.",

keywords = "Asymptomatic pathogenic escherichia coli, Atypical EPEC, Diarrhoea, Enteropathogenic escherichia coli, Epidemiology",

author = "J. Hu and Torres, {A. G.}",

note = "Publisher Copyright: {\textcopyright} 2015 European Society of Clinical Microbiology and Infectious Diseases.",

year = "2015",

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T1 - Enteropathogenic Escherichia coli

T2 - Foe or innocent bystander?

AU - Hu, J.

AU - Torres, A. G.

PY - 2015/8/1

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N2 - Enteropathogenic Escherichia coli (EPEC) remain one the most important pathogens infecting children and they are one of the main causes of persistent diarrhoea worldwide. Historically, typical EPEC (tEPEC), defined as those isolates with the attaching and effacement (A/E) genotype (eae+), which possess bfpA+ and lack the stx- genes are found strongly associated with diarrhoeal cases. However, occurrence of atypical EPEC (aEPEC; eae+ bfpA- stx-) in diarrhoeal and asymptomatic hosts has made investigators question the role of these pathogens in human disease. Current epidemiological data are helping to answer the question of whether EPEC is mainly a foe or an innocent bystander during infection.

AB - Enteropathogenic Escherichia coli (EPEC) remain one the most important pathogens infecting children and they are one of the main causes of persistent diarrhoea worldwide. Historically, typical EPEC (tEPEC), defined as those isolates with the attaching and effacement (A/E) genotype (eae+), which possess bfpA+ and lack the stx- genes are found strongly associated with diarrhoeal cases. However, occurrence of atypical EPEC (aEPEC; eae+ bfpA- stx-) in diarrhoeal and asymptomatic hosts has made investigators question the role of these pathogens in human disease. Current epidemiological data are helping to answer the question of whether EPEC is mainly a foe or an innocent bystander during infection.

KW - Asymptomatic pathogenic escherichia coli

KW - Atypical EPEC

KW - Diarrhoea

KW - Enteropathogenic escherichia coli

KW - Epidemiology

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JO - Clinical Microbiology and Infection

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ER -

Enteropathogenic Escherichia coli: Foe or innocent bystander?

Abstract

Keywords

ASJC Scopus subject areas

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