Epidemic occurrence of neonatal necrotizing enterocolitis

M. Guinan, D. Schaberg, F. W. Bruhn, Carol Richardson, W. W. Fox

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In case-control studies of three epidemics of neonatal necrotizing enterocolitis (NEC) in three different high-risk nurseries in three states, no particular risk factor was associated with affected infants or their mothers. Epidemic cases had higher birth weights and Apgar scores and fewer perinatal difficulties than those previously reported for sporadic cases. Seven infants fed primarily breast milk were not protected against disease. Early antibiotic therapy was associated with a significantly decreased risk of disease in one outbreak. In two hospitals, affected infants who received antibiotic therapy during the first three days of life had a significantly later disease onset. The occurrence of the disease in epidemics and the decreased risk or modification of disease with antibiotic therapy support an infectious etiology for NEC.

Original languageEnglish (US)
Pages (from-to)594-597
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume133
Issue number6
StatePublished - 1979
Externally publishedYes

Fingerprint

Necrotizing Enterocolitis
Anti-Bacterial Agents
Apgar Score
Nurseries
Human Milk
Secondary Prevention
Birth Weight
Disease Outbreaks
Case-Control Studies
Mothers
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Guinan, M., Schaberg, D., Bruhn, F. W., Richardson, C., & Fox, W. W. (1979). Epidemic occurrence of neonatal necrotizing enterocolitis. American Journal of Diseases of Children, 133(6), 594-597.

Epidemic occurrence of neonatal necrotizing enterocolitis. / Guinan, M.; Schaberg, D.; Bruhn, F. W.; Richardson, Carol; Fox, W. W.

In: American Journal of Diseases of Children, Vol. 133, No. 6, 1979, p. 594-597.

Research output: Contribution to journalArticle

Guinan, M, Schaberg, D, Bruhn, FW, Richardson, C & Fox, WW 1979, 'Epidemic occurrence of neonatal necrotizing enterocolitis', American Journal of Diseases of Children, vol. 133, no. 6, pp. 594-597.
Guinan, M. ; Schaberg, D. ; Bruhn, F. W. ; Richardson, Carol ; Fox, W. W. / Epidemic occurrence of neonatal necrotizing enterocolitis. In: American Journal of Diseases of Children. 1979 ; Vol. 133, No. 6. pp. 594-597.
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