Epidemiological investigations following an outbreak of hemorrhagic fever with renal syndrome in Greece

James LeDuc, A. Antoniades, K. Siamopoulos

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Epidemiological investigations were conducted following an outbreak of hemorrhagic fever with renal syndrome (HFRS) which occurred in the state of Epirus, north-western Greece, in July and August 1983. A total of 8 patients were hospitalized during the outbreak; 3 were severely ill and 1 died. A serosurvey made in May 1984 sampled 184 of the approximately 400 residents of the village of Tsepelovo, where 4 patients resided, and found 12 (6.5%) persons, including convalescent sera from 4 patients, with antihantaviral antibody by immunofluorescent antibody (IFA) tests. Small mammal collections found house rats common in the village, but none exhibited anti-hantaviral antibody. Collections in nearby fields and mountains found Apodemus flavicollis rodents common, and 2 (6%) of 33 captured had high IFA anti-hantavirus antibody. Virus isolation attempts from rodent tissues were unsuccessful. Testing of convalescent patients' sera by IFA and plaque reduction neutralization tests indicated that the etiological agent was neither Pumuala virus nor Seoul virus, but appears to be a strain of Hantaan virus or perhaps a new virus. The rodent host of this virus may be A. flavicollis, and the distribution of this species corresponds with previously reported cases of severe HFRS described elsewhere in central Europe.

Original languageEnglish (US)
Pages (from-to)654-659
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume35
Issue number3
StatePublished - 1986
Externally publishedYes

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Hemorrhagic Fever with Renal Syndrome
Greece
Disease Outbreaks
Viruses
Rodentia
Antibodies
Seoul virus
Anti-Idiotypic Antibodies
Hantaan virus
Hantavirus
Murinae
Neutralization Tests
Serum
Mammals

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Epidemiological investigations following an outbreak of hemorrhagic fever with renal syndrome in Greece. / LeDuc, James; Antoniades, A.; Siamopoulos, K.

In: American Journal of Tropical Medicine and Hygiene, Vol. 35, No. 3, 1986, p. 654-659.

Research output: Contribution to journalArticle

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