TY - JOUR
T1 - EpidemiologiCal POpulatioN STudy of SARS-CoV-2 in Lake CounTy, Illinois (CONTACT)
T2 - Methodology and Baseline Characteristics of a Community-Based Surveillance Study
AU - Kilpatrick, Ryan D.
AU - Sánchez-Soliño, Olga
AU - Alami, Negar Niki
AU - Johnson, Christopher
AU - Fang, Yixin
AU - Wegrzyn, Lani R.
AU - Krueger, Whitney S.
AU - Ye, Yizhou
AU - Dreyer, Nancy
AU - Gray, Gregory C.
N1 - Funding Information:
This work/study as well as the journal’s Rapid Service Fee were funded by AbbVie Inc. AbbVie participated in the study design, research, data collection, analysis, and interpretation of data, writing, reviewing, and approving the publication. All authors had access to the data results, and participated in the development, review, and approval of this manuscript. No honoraria or payments were made for authorship.
Funding Information:
The authors would like to express their gratitude to the study participants and their family members who made this study possible. This work/study as well as the journal?s Rapid Service Fee were funded by AbbVie Inc. AbbVie participated in the study design, research, data collection, analysis, and interpretation of data, writing, reviewing, and approving the publication. All authors had access to the data results, and participated in the development, review, and approval of this manuscript. No honoraria or payments were made for authorship. Medical writing support was provided by Brandy Menges, PhD, of Fishawack Communications Ltd., a member of Fishawack Health, and funded by AbbVie. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Ryan D. Kilpatrick, Olga S?nchez-Soli?o, Negar Niki Alami, Christopher Johnson, Yixin Fang, Lani R. Wegrzyn, Whitney S. Krueger, and Yizhou Ye contributed to the conception and design of the study and analysis of data. All authors (Ryan D. Kilpatrick, Olga S?nchez-Soli?o, Negar Niki Alami, Christopher Johnson, Yixin Fang, Lani R. Wegrzyn, Whitney S. Krueger, Yizhou Ye, Nancy Dreyer, and Gregory Gray) contributed to the interpretation of data, critical revision of the manuscript, agree to be accountable for ensuring the integrity and accuracy of the work, and approved the final version of the manuscript. Ryan D. Kilpatrick, Olga S?nchez-Soli?o, Negar Niki Alami, Christopher Johnson, Yixin Fang, Lani R. Wegrzyn, Whitney S. Krueger, and Yizhou Ye are employees of AbbVie and may hold stock options. Nancy Dreyer is a full-time employee of IQVIA. Gregory Gray previously served as a paid consultant to AbbVie, Inc and is currently employed at the University of Texas Medical Branch, Galveston, Texas. The protocol, informed consent form, and all communications to study participants including advertising pieces were reviewed and approved by an Institutional Review Board (Advarra, Inc). All participants provided informed consent prior to completion of questionnaires and specimen collection. All data generated or analyzed during this study are included in this published article and associated supplementary material files.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/4
Y1 - 2022/4
N2 - Introduction: EpidemiologiCal POpulatioN STudy of SARS-CoV-2 in Lake CounTy, Illinois (CONTACT) is an observational, epidemiological study with a 9-month longitudinal follow-up of nonhospitalized persons aged 18 years or older currently living or employed in Lake County, IL. We describe the study design and report baseline characteristics of the study participants, including the proportion of participants with acute or previous SARS-CoV-2 infection at enrollment. Methods: At enrollment and subsequent timepoints, participants recruited through digital and paper-based advertising campaigns reported their occupational and school-based exposure, risk factors, and behaviors, and provided nasal and serum specimens. Stratified enrichment was used to enhance enrollment into medium- and higher-risk groups within four occupational risk groups for SARS-CoV-2 infection. RT-PCR and serologic (IgG) testing were conducted to detect acute or previous SARS-CoV-2 infection in participants, respectively. Results: Between November 2020 and January 2021, 1008 participants (female 70.7%, mean age ± SD 51 ± 13.8 years) completed the questionnaire and diagnostic testing. Among participants, 41.8% (n = 421) were considered low risk, 24.6% (n = 248) were medium-to-low risk, 22.3% (n = 225) were medium-to-high risk, and 11.3% (n = 114) were high risk. Of 56 (5.6%) participants with evidence of acute or previous SARS-CoV-2 infection at baseline, 11 (19.6%) were RT-PCR-positive, 36 (64.3%) were IgG-seropositive, and 9 (16.1%) were positive by both assays. Participants who were adherent vs nonadherent to social distancing measures (odds ratio [95% CI] 0.8 [0.4–1.8]) were less likely, while those in higher vs lower occupational risk groups (2.0 [1.0–4.4]) were more likely to have evidence for acute or previous SARS-CoV-2 infection. Conclusion: In fall/winter 2020/21, 5.6% of adults in a Lake County convenience sample had evidence for acute or previous SARS-CoV-2 infection at baseline. Nonadherence to social distancing measures and high-risk professions were associated with SARS-CoV-2 infection. The study is ongoing and future analyses will assess infection status over time. Clinical Trial Registration: NCT04611230.
AB - Introduction: EpidemiologiCal POpulatioN STudy of SARS-CoV-2 in Lake CounTy, Illinois (CONTACT) is an observational, epidemiological study with a 9-month longitudinal follow-up of nonhospitalized persons aged 18 years or older currently living or employed in Lake County, IL. We describe the study design and report baseline characteristics of the study participants, including the proportion of participants with acute or previous SARS-CoV-2 infection at enrollment. Methods: At enrollment and subsequent timepoints, participants recruited through digital and paper-based advertising campaigns reported their occupational and school-based exposure, risk factors, and behaviors, and provided nasal and serum specimens. Stratified enrichment was used to enhance enrollment into medium- and higher-risk groups within four occupational risk groups for SARS-CoV-2 infection. RT-PCR and serologic (IgG) testing were conducted to detect acute or previous SARS-CoV-2 infection in participants, respectively. Results: Between November 2020 and January 2021, 1008 participants (female 70.7%, mean age ± SD 51 ± 13.8 years) completed the questionnaire and diagnostic testing. Among participants, 41.8% (n = 421) were considered low risk, 24.6% (n = 248) were medium-to-low risk, 22.3% (n = 225) were medium-to-high risk, and 11.3% (n = 114) were high risk. Of 56 (5.6%) participants with evidence of acute or previous SARS-CoV-2 infection at baseline, 11 (19.6%) were RT-PCR-positive, 36 (64.3%) were IgG-seropositive, and 9 (16.1%) were positive by both assays. Participants who were adherent vs nonadherent to social distancing measures (odds ratio [95% CI] 0.8 [0.4–1.8]) were less likely, while those in higher vs lower occupational risk groups (2.0 [1.0–4.4]) were more likely to have evidence for acute or previous SARS-CoV-2 infection. Conclusion: In fall/winter 2020/21, 5.6% of adults in a Lake County convenience sample had evidence for acute or previous SARS-CoV-2 infection at baseline. Nonadherence to social distancing measures and high-risk professions were associated with SARS-CoV-2 infection. The study is ongoing and future analyses will assess infection status over time. Clinical Trial Registration: NCT04611230.
KW - COVID-19
KW - Community-based research
KW - Epidemiology
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85124130105&partnerID=8YFLogxK
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U2 - 10.1007/s40121-022-00593-0
DO - 10.1007/s40121-022-00593-0
M3 - Article
AN - SCOPUS:85124130105
SN - 2193-8229
VL - 11
SP - 899
EP - 911
JO - Infectious Diseases and Therapy
JF - Infectious Diseases and Therapy
IS - 2
ER -