Epidemiology and differential diagnosis of nasal polyps

Mohamad Chaaban, Erika M. Walsh, Bradford A. Woodworth

Research output: Contribution to journalReview article

56 Citations (Scopus)

Abstract

Background: Chronic rhinosinusitis (CRS) is one of the most common chronic medical conditions, with a significant impact on patient quality of life. CRS is broadly classified into two groups: CRS with nasal polyposis (CRSwNP) and CRS without NP (CRSsNP). Clinically, the major subtypes of CRSwNP may be divided into eosinophilic chronic rhinosinusitis (e.g., allergic fungal rhinosinusitis and aspirin-exacerbated respiratory disease [AERD]) and nasal polyps associated with neutrophilic inflammation (e.g., cystic fibrosis [CF]). CF is characterized by mutation of the gene encoding the CF transmembrane conductance regulator. Functional endoscopic sinus surgery is usually required for most NP patients with increased frequency in patients with AERD. This study provides a review of the epidemiology and major classification of CRSwNP. Methods: A review was performed of the literature regarding different subtypes of CRSwNP. Results: Many definitions of CRSwNP exist and estimates of prevalence vary. Conclusion: CRSwNP is a clinical syndrome with a heterogeneous inflammatory profile. Of the subtypes associated with eosinophilic inflammation, AERD remains the most recalcitrant to medical and surgical therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)473-478
Number of pages6
JournalAmerican Journal of Rhinology and Allergy
Volume27
Issue number6
DOIs
StatePublished - Nov 2013
Externally publishedYes

Fingerprint

Nasal Polyps
Nose
Epidemiology
Differential Diagnosis
Aspirin
Cystic Fibrosis
Inflammation
Cystic Fibrosis Transmembrane Conductance Regulator
Quality of Life
Mutation
Genes

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Immunology and Allergy

Cite this

Epidemiology and differential diagnosis of nasal polyps. / Chaaban, Mohamad; Walsh, Erika M.; Woodworth, Bradford A.

In: American Journal of Rhinology and Allergy, Vol. 27, No. 6, 11.2013, p. 473-478.

Research output: Contribution to journalReview article

Chaaban, Mohamad ; Walsh, Erika M. ; Woodworth, Bradford A. / Epidemiology and differential diagnosis of nasal polyps. In: American Journal of Rhinology and Allergy. 2013 ; Vol. 27, No. 6. pp. 473-478.
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