Epidemiology and pathogenesis of Bolivian hemorrhagic fever

Michael Patterson, Ashley Grant, Slobodan Paessler

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV) is reported to have a mortality rate of 25-35%. First identified in 1959, BHF was the cause of a localized outbreak in San Joaquin until rodent population controls were implemented in 1964. The rodent Calomys collosus was identified as the primary vector and reservoir for the virus. Multiple animal models were considered during the 1970s with the most human-like disease identified in Rhesus macaques but minimal characterization of the pathogenesis has been published since. A reemergence of reported BHF cases has been reported in recent years, which necessitates the further study and development of a vaccine to prevent future outbreaks.

Original languageEnglish (US)
Pages (from-to)82-90
Number of pages9
JournalCurrent Opinion in Virology
Volume5
Issue number1
DOIs
StatePublished - 2014

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American Hemorrhagic Fever
New World Arenaviruses
Disease Outbreaks
Epidemiology
Rodent Control
Population Control
Macaca mulatta
Rodentia
Vaccines
Animal Models
Viruses
Mortality

ASJC Scopus subject areas

  • Virology
  • Medicine(all)

Cite this

Epidemiology and pathogenesis of Bolivian hemorrhagic fever. / Patterson, Michael; Grant, Ashley; Paessler, Slobodan.

In: Current Opinion in Virology, Vol. 5, No. 1, 2014, p. 82-90.

Research output: Contribution to journalArticle

Patterson, Michael ; Grant, Ashley ; Paessler, Slobodan. / Epidemiology and pathogenesis of Bolivian hemorrhagic fever. In: Current Opinion in Virology. 2014 ; Vol. 5, No. 1. pp. 82-90.
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