Epidemiology and pathogenesis of maternal-fetal transmission of Trypanosoma cruzi and a case for vaccine development against congenital Chagas disease

Lizette Rios, E. Emanuel Campos, Ramkumar Menon, M. Paola Zago, Nisha J. Garg

Research output: Contribution to journalReview article

Abstract

Trypanos o ma cruzi (T. cruzi or Tc) is the causative agent of Chagas disease (CD). It is common for patients to suffer from non-specific symptoms or be clinically asymptomatic with acute and chronic conditions acquired through various routes of transmission. The expecting women and their fetuses are vulnerable to congenital transmission of Tc. Pregnant women face formidable health challenges because the frontline antiparasitic drugs, benznidazole and nifurtimox, are contraindicated during pregnancy. However, it is worthwhile to highlight that newborns can be cured if they are diagnosed and given treatment in a timely manner. In this review, we discuss the pathogenesis of maternal-fetal transmission of Tc and provide a justification for the investment in the development of vaccines against congenital CD.

Original languageEnglish (US)
Article number165591
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Chagas Disease
Trypanosoma cruzi
Epidemiology
Nifurtimox
Vaccines
Mothers
Antiparasitic Agents
Pregnant Women
Fetus
Newborn Infant
Pregnancy
Health
Therapeutics
benzonidazole

Keywords

  • Chagas
  • Congenital
  • Maternal-fetal transmission
  • Trypanosoma cruzi
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

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title = "Epidemiology and pathogenesis of maternal-fetal transmission of Trypanosoma cruzi and a case for vaccine development against congenital Chagas disease",
abstract = "Trypanos o ma cruzi (T. cruzi or Tc) is the causative agent of Chagas disease (CD). It is common for patients to suffer from non-specific symptoms or be clinically asymptomatic with acute and chronic conditions acquired through various routes of transmission. The expecting women and their fetuses are vulnerable to congenital transmission of Tc. Pregnant women face formidable health challenges because the frontline antiparasitic drugs, benznidazole and nifurtimox, are contraindicated during pregnancy. However, it is worthwhile to highlight that newborns can be cured if they are diagnosed and given treatment in a timely manner. In this review, we discuss the pathogenesis of maternal-fetal transmission of Tc and provide a justification for the investment in the development of vaccines against congenital CD.",
keywords = "Chagas, Congenital, Maternal-fetal transmission, Trypanosoma cruzi, Vaccine",
author = "Lizette Rios and Campos, {E. Emanuel} and Ramkumar Menon and Zago, {M. Paola} and Garg, {Nisha J.}",
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AU - Rios, Lizette

AU - Campos, E. Emanuel

AU - Menon, Ramkumar

AU - Zago, M. Paola

AU - Garg, Nisha J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Trypanos o ma cruzi (T. cruzi or Tc) is the causative agent of Chagas disease (CD). It is common for patients to suffer from non-specific symptoms or be clinically asymptomatic with acute and chronic conditions acquired through various routes of transmission. The expecting women and their fetuses are vulnerable to congenital transmission of Tc. Pregnant women face formidable health challenges because the frontline antiparasitic drugs, benznidazole and nifurtimox, are contraindicated during pregnancy. However, it is worthwhile to highlight that newborns can be cured if they are diagnosed and given treatment in a timely manner. In this review, we discuss the pathogenesis of maternal-fetal transmission of Tc and provide a justification for the investment in the development of vaccines against congenital CD.

AB - Trypanos o ma cruzi (T. cruzi or Tc) is the causative agent of Chagas disease (CD). It is common for patients to suffer from non-specific symptoms or be clinically asymptomatic with acute and chronic conditions acquired through various routes of transmission. The expecting women and their fetuses are vulnerable to congenital transmission of Tc. Pregnant women face formidable health challenges because the frontline antiparasitic drugs, benznidazole and nifurtimox, are contraindicated during pregnancy. However, it is worthwhile to highlight that newborns can be cured if they are diagnosed and given treatment in a timely manner. In this review, we discuss the pathogenesis of maternal-fetal transmission of Tc and provide a justification for the investment in the development of vaccines against congenital CD.

KW - Chagas

KW - Congenital

KW - Maternal-fetal transmission

KW - Trypanosoma cruzi

KW - Vaccine

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