Epidemiology and pathogenesis of maternal-fetal transmission of Trypanosoma cruzi and a case for vaccine development against congenital Chagas disease

Lizette Rios, E. Emanuel Campos, Ramkumar Menon, M. Paola Zago, Nisha J. Garg

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Trypanos o ma cruzi (T. cruzi or Tc) is the causative agent of Chagas disease (CD). It is common for patients to suffer from non-specific symptoms or be clinically asymptomatic with acute and chronic conditions acquired through various routes of transmission. The expecting women and their fetuses are vulnerable to congenital transmission of Tc. Pregnant women face formidable health challenges because the frontline antiparasitic drugs, benznidazole and nifurtimox, are contraindicated during pregnancy. However, it is worthwhile to highlight that newborns can be cured if they are diagnosed and given treatment in a timely manner. In this review, we discuss the pathogenesis of maternal-fetal transmission of Tc and provide a justification for the investment in the development of vaccines against congenital CD.

Original languageEnglish (US)
Article number165591
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1866
Issue number3
DOIs
StatePublished - Mar 1 2020

Keywords

  • Chagas
  • Congenital
  • Maternal-fetal transmission
  • Trypanosoma cruzi
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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