Epidemiology, evolution, and recent outbreaks of avian influenza virus in China

Shuo Su, Yuhai Bi, Gary Wong, Gregory C. Gray, George F. Gao, Shoujun Li

Research output: Contribution to journalArticlepeer-review

203 Scopus citations


Novel reassortants of H7N9, H10N8, and H5N6 avian influenza viruses (AIVs) are currently circulating in China's poultry flocks, occasionally infecting humans and other mammals. Combined with the sometimes enzootic H5N1 and H9N2 strains, this cauldron of genetically diverse AIVs pose significant risks to public health. Here, we review the epidemiology, evolution, and recent outbreaks of AIVs in China, discuss reasons behind the recent increase in the emergence of novel AIVs, and identify warning signs which may point to the emergence of a potentially virulent and highly transmissible AIV to humans. This review will be useful to authorities who consider options for the detection and control of AIV transmission in animals and humans, with the goal of preventing future epidemics and pandemics.

Original languageEnglish (US)
Pages (from-to)8671-8676
Number of pages6
JournalJournal of virology
Issue number17
StatePublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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