Epidemiology, molecular biology, and pathogenic mechanisms of Ehrlichia infections

Xue Jie Yu, David Walker

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Ehrlichia are tick-borne, obligately intracellular Gram negative bacteria and are important veterinary and human pathogens with a worldwide distribution. Ehrlichia can cause prolonged or persistent infection in animal hosts. The pathogenesis of Ehrlichia is mediated principally by the immune response. In order to multiple inside host cell, Ehrlichia passively escape host innate immunity (such as pattern recognition receptors) due to lack of typical Gram negative bacterial cell wall components (such as lipopolysacchride and peptidoglycan) and actively encoded proteins that enter into host cell nucleus to manipulate host cell gene expression.

Original languageEnglish (US)
Title of host publicationRickettsiales
Subtitle of host publicationBiology, Molecular Biology, Epidemiology, and Vaccine Development
PublisherSpringer International Publishing
Pages225-240
Number of pages16
ISBN (Electronic)9783319468594
ISBN (Print)9783319468570
DOIs
StatePublished - Jan 1 2016

Keywords

  • Ankyrin repeat
  • Ehrlichia
  • Ehrlichiosis
  • Epidemiology
  • Genome reduction
  • Immune subversion
  • Ticks

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Yu, X. J., & Walker, D. (2016). Epidemiology, molecular biology, and pathogenic mechanisms of Ehrlichia infections. In Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development (pp. 225-240). Springer International Publishing. https://doi.org/10.1007/978-3-319-46859-4_12