Epidemiology of Clostridium difficile-associated diarrhea in a Peruvian tertiary care hospital

Coralith Garcia, Frine Samalvides, Margot Vidal, Eduardo Gotuzzo, Herbert L. Dupont

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The prevalence, incidence, and epidemiologic factors of Clostridium difficile-associated diarrhea (CDAD) in a Peruvian hospital were studied. We conducted a cross-sectional study in patients > 14 years of age from medical/surgical wards of the Cayetano Heredia National Hospital (Lima, Peru) from September 2005 to May 2006. CDAD was defined in a case of nosocomial diarrhea when C. difficile toxin A and/or toxin B was detected by enzyme immune assay (EIA) in stools. A total of 4,264 patients were admitted, with 156 (3.7%) developing nosocomial diarrhea. Fifty-five of 156 (35.2%) cases of nosocomial diarrhea were diagnosed as CDAD. The overall incidence per 1,000 admissions was 12.9. Multivariate analysis showed that use of diapers (OR, 3.54; 95% CI, 1.71-7.34; P = 0.001) and presence of another patient with CDAD housed in the same room (OR, 2.97; 95% CI, 1.14-7.76; P = 0.026) were significantly associated with CDAD. Hospital transmission of C. difficile commonly occurred, supporting infection-appropriate measures directed toward the reduction of CDAD in low-resource settings.

Original languageEnglish (US)
Pages (from-to)802-805
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume77
Issue number5
StatePublished - Nov 2007
Externally publishedYes

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Clostridium difficile
Tertiary Healthcare
Tertiary Care Centers
Diarrhea
Epidemiology
Epidemiologic Factors
Peru
Incidence
Enzyme Assays
Multivariate Analysis
Cross-Sectional Studies

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Medicine(all)

Cite this

Garcia, C., Samalvides, F., Vidal, M., Gotuzzo, E., & Dupont, H. L. (2007). Epidemiology of Clostridium difficile-associated diarrhea in a Peruvian tertiary care hospital. American Journal of Tropical Medicine and Hygiene, 77(5), 802-805.

Epidemiology of Clostridium difficile-associated diarrhea in a Peruvian tertiary care hospital. / Garcia, Coralith; Samalvides, Frine; Vidal, Margot; Gotuzzo, Eduardo; Dupont, Herbert L.

In: American Journal of Tropical Medicine and Hygiene, Vol. 77, No. 5, 11.2007, p. 802-805.

Research output: Contribution to journalArticle

Garcia, C, Samalvides, F, Vidal, M, Gotuzzo, E & Dupont, HL 2007, 'Epidemiology of Clostridium difficile-associated diarrhea in a Peruvian tertiary care hospital', American Journal of Tropical Medicine and Hygiene, vol. 77, no. 5, pp. 802-805.
Garcia, Coralith ; Samalvides, Frine ; Vidal, Margot ; Gotuzzo, Eduardo ; Dupont, Herbert L. / Epidemiology of Clostridium difficile-associated diarrhea in a Peruvian tertiary care hospital. In: American Journal of Tropical Medicine and Hygiene. 2007 ; Vol. 77, No. 5. pp. 802-805.
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