Epidemiology of Ebola (subtype Reston) virus in the Philippines, 1996

M. E. Miranda, Thomas Ksiazek, T. J. Retuya, Ali S. Khan, Anthony Sanchez, Charles F. Fulhorst, Pierre E. Rollin, A. B. Calaor, D. L. Manalo, M. C. Roces, M. M. Dayrit, C. J. Peters

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Ebola (subtype Reston [EBO-R]) virus infection was detected in macaques imported into the United States from the Philippines in March 1996. Studies were initiated in the Philippines to identify the source of the virus among monkey-breeding and export facilities, to establish surveillance and testing, and to assess the risk and significance of EBO-R infections in humans who work in these facilities. Over a 5-month period, acutely infected animals were found at only one facility, as determined using Ebola antigen detection. Three of 1732 monkeys and 1 of 246 animal handlers tested had detectable antibodies; all were from the same facility, which was the source of infected monkeys imported to the United States. Virus transmission, which was facilitated by poor infection-control practices, continued for several months in one facility and was stopped only when the facility was depopulated. None of the 246 employees of the facilities or 4 contacts of previously antibody- positive individuals reported an Ebola-like illness. This investigation suggests that human EBO-R infection is rare.

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume179
Issue numberSUPPL. 1
StatePublished - 1999
Externally publishedYes

Fingerprint

Ebolavirus
Philippines
Haplorhini
Epidemiology
Viruses
Antibodies
Macaca
Virus Diseases
Infection Control
Infection
Breeding
Antigens
Reston

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Miranda, M. E., Ksiazek, T., Retuya, T. J., Khan, A. S., Sanchez, A., Fulhorst, C. F., ... Peters, C. J. (1999). Epidemiology of Ebola (subtype Reston) virus in the Philippines, 1996. Journal of Infectious Diseases, 179(SUPPL. 1).

Epidemiology of Ebola (subtype Reston) virus in the Philippines, 1996. / Miranda, M. E.; Ksiazek, Thomas; Retuya, T. J.; Khan, Ali S.; Sanchez, Anthony; Fulhorst, Charles F.; Rollin, Pierre E.; Calaor, A. B.; Manalo, D. L.; Roces, M. C.; Dayrit, M. M.; Peters, C. J.

In: Journal of Infectious Diseases, Vol. 179, No. SUPPL. 1, 1999.

Research output: Contribution to journalArticle

Miranda, ME, Ksiazek, T, Retuya, TJ, Khan, AS, Sanchez, A, Fulhorst, CF, Rollin, PE, Calaor, AB, Manalo, DL, Roces, MC, Dayrit, MM & Peters, CJ 1999, 'Epidemiology of Ebola (subtype Reston) virus in the Philippines, 1996', Journal of Infectious Diseases, vol. 179, no. SUPPL. 1.
Miranda ME, Ksiazek T, Retuya TJ, Khan AS, Sanchez A, Fulhorst CF et al. Epidemiology of Ebola (subtype Reston) virus in the Philippines, 1996. Journal of Infectious Diseases. 1999;179(SUPPL. 1).
Miranda, M. E. ; Ksiazek, Thomas ; Retuya, T. J. ; Khan, Ali S. ; Sanchez, Anthony ; Fulhorst, Charles F. ; Rollin, Pierre E. ; Calaor, A. B. ; Manalo, D. L. ; Roces, M. C. ; Dayrit, M. M. ; Peters, C. J. / Epidemiology of Ebola (subtype Reston) virus in the Philippines, 1996. In: Journal of Infectious Diseases. 1999 ; Vol. 179, No. SUPPL. 1.
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