Epidemiology of hepatitis B in eastern Kenya

K. C. Hyams, F. A. Okoth, P. M. Tukei, M. Mugambi, B. Johnson, J. C. Morrill, G. C. Gray, J. N. Woody

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A cross-sectional survey of outpatients attending the three district hospitals in the towns of Mombasa, Kilifi, and Malindi was conducted to determine the patterns of hepatitis B transmission in eastern Kenya. Of 1,533 study subjects (mean age 21.9 ± 13.2 years; range, 4 months to 80 years), 11.4% were positive for HBsAg and 56.2% were seropositive for at least one hepatitis B marker (HBsAg, anti-HBs, or anti-HBc). Antidelta antibody was found in 1.2% of HBsAG-positive samples. HBeAg was found in 36.0% of HBsAg-positive samples obtained from women of childbearing age. The prevalence of seropositivity for hepatitis B markers was positively correlated with age, increasing from 20% in subjects less than 4 years old to more than 80% in study subjects greater than 40 years old. On multivariate analysis, male sex was found to be associated with HBsAg positivity, and age and previous deliveries of children were associated with seropositivity for any hepatitis marker (HBsAg, anti-HBs, or anti-HBc). An effective hepatitis B immunization strategy in this region of Kenya would require vaccination early in life because a major portion of hepatitis B transmission occurs in childhood.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
JournalJournal of Medical Virology
Volume28
Issue number2
StatePublished - 1989
Externally publishedYes

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Kenya
Hepatitis B Surface Antigens
Hepatitis B
Epidemiology
Hepatitis B e Antigens
District Hospitals
Hepatitis
Immunization
Vaccination
Outpatients
Multivariate Analysis
Cross-Sectional Studies
Antibodies

ASJC Scopus subject areas

  • Virology

Cite this

Hyams, K. C., Okoth, F. A., Tukei, P. M., Mugambi, M., Johnson, B., Morrill, J. C., ... Woody, J. N. (1989). Epidemiology of hepatitis B in eastern Kenya. Journal of Medical Virology, 28(2), 106-109.

Epidemiology of hepatitis B in eastern Kenya. / Hyams, K. C.; Okoth, F. A.; Tukei, P. M.; Mugambi, M.; Johnson, B.; Morrill, J. C.; Gray, G. C.; Woody, J. N.

In: Journal of Medical Virology, Vol. 28, No. 2, 1989, p. 106-109.

Research output: Contribution to journalArticle

Hyams, KC, Okoth, FA, Tukei, PM, Mugambi, M, Johnson, B, Morrill, JC, Gray, GC & Woody, JN 1989, 'Epidemiology of hepatitis B in eastern Kenya', Journal of Medical Virology, vol. 28, no. 2, pp. 106-109.
Hyams KC, Okoth FA, Tukei PM, Mugambi M, Johnson B, Morrill JC et al. Epidemiology of hepatitis B in eastern Kenya. Journal of Medical Virology. 1989;28(2):106-109.
Hyams, K. C. ; Okoth, F. A. ; Tukei, P. M. ; Mugambi, M. ; Johnson, B. ; Morrill, J. C. ; Gray, G. C. ; Woody, J. N. / Epidemiology of hepatitis B in eastern Kenya. In: Journal of Medical Virology. 1989 ; Vol. 28, No. 2. pp. 106-109.
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