Epidemiology of methicillin-resistant staphylococcus aureus in a university medical center day care facility

Angela L. Hewlett, Pamela S. Falk, Katrina S. Hughes, C. Glen Mayhall

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

objective. Few data are available on methicillin-resistant Staphylococcus aureus (MRSA) colonization in day care. We performed a study in a medical university child care center to study the epidemiology of MRSA in this population. design. Survey. setting. A child care center on the campus of a university medical center. methods. One hundred four children who attended the child care center and 32 employees gave samples that were cultured for MRSA. Seventeen household members of the children and employee found to be colonized with MRSA also gave samples that were cultured. Parents and employees completed questionnaires about demographic characteristics, medical conditions and treatments, and possible exposure risks outside the child care center. In addition, 195 environmental samples were taken from sites at the childcare center. Isolates were analyzed for relatedness by use of molecular typing, and statistical analysis was performed. results. The prevalence of MRSA in the children was 6.7%. One employee (3.1%) was colonized with MRSA. Cultures of samples given by 6 of 17 (35.3%) family members of these children and the employee yielded MRSA. MRSA was recovered from 4 of 195 environmental samples. Molecular typing revealed that many of the MRSA isolates were indistinguishable, and 18 of the 21 isolates were communityassociated MRSA. Multivariable analysis revealed that receipt of macrolide antibiotics ( ; odds ratio, 39.6 [95% confidence intervalPp.002, 3.4-651.4]) and receipt of asthma medications (Pp.024; odds ratio, 26.9 [95% confidence interval, 1.5-500.7]) were related to MRSA colonization. conclusions. There was a low prevalence of MRSA colonization in children and employees in the child care center but a higher prevalence of colonization in their families. Molecular typing showed that transmission of MRSA likely occurred in the child care center. The use of macrolide antibiotics and asthma medications may increase the risk of MRSA colonization in this population.

Original languageEnglish (US)
Pages (from-to)985-992
Number of pages8
JournalInfection Control and Hospital Epidemiology
Volume30
Issue number10
DOIs
StatePublished - Oct 2009

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Medical Day Care
Methicillin-Resistant Staphylococcus aureus
Epidemiology
Child Care
Molecular Typing
Macrolides
Asthma
Odds Ratio
Anti-Bacterial Agents
Population

ASJC Scopus subject areas

  • Microbiology (medical)
  • Epidemiology
  • Infectious Diseases

Cite this

Epidemiology of methicillin-resistant staphylococcus aureus in a university medical center day care facility. / Hewlett, Angela L.; Falk, Pamela S.; Hughes, Katrina S.; Mayhall, C. Glen.

In: Infection Control and Hospital Epidemiology, Vol. 30, No. 10, 10.2009, p. 985-992.

Research output: Contribution to journalArticle

Hewlett, Angela L. ; Falk, Pamela S. ; Hughes, Katrina S. ; Mayhall, C. Glen. / Epidemiology of methicillin-resistant staphylococcus aureus in a university medical center day care facility. In: Infection Control and Hospital Epidemiology. 2009 ; Vol. 30, No. 10. pp. 985-992.
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abstract = "objective. Few data are available on methicillin-resistant Staphylococcus aureus (MRSA) colonization in day care. We performed a study in a medical university child care center to study the epidemiology of MRSA in this population. design. Survey. setting. A child care center on the campus of a university medical center. methods. One hundred four children who attended the child care center and 32 employees gave samples that were cultured for MRSA. Seventeen household members of the children and employee found to be colonized with MRSA also gave samples that were cultured. Parents and employees completed questionnaires about demographic characteristics, medical conditions and treatments, and possible exposure risks outside the child care center. In addition, 195 environmental samples were taken from sites at the childcare center. Isolates were analyzed for relatedness by use of molecular typing, and statistical analysis was performed. results. The prevalence of MRSA in the children was 6.7{\%}. One employee (3.1{\%}) was colonized with MRSA. Cultures of samples given by 6 of 17 (35.3{\%}) family members of these children and the employee yielded MRSA. MRSA was recovered from 4 of 195 environmental samples. Molecular typing revealed that many of the MRSA isolates were indistinguishable, and 18 of the 21 isolates were communityassociated MRSA. Multivariable analysis revealed that receipt of macrolide antibiotics ( ; odds ratio, 39.6 [95{\%} confidence intervalPp.002, 3.4-651.4]) and receipt of asthma medications (Pp.024; odds ratio, 26.9 [95{\%} confidence interval, 1.5-500.7]) were related to MRSA colonization. conclusions. There was a low prevalence of MRSA colonization in children and employees in the child care center but a higher prevalence of colonization in their families. Molecular typing showed that transmission of MRSA likely occurred in the child care center. The use of macrolide antibiotics and asthma medications may increase the risk of MRSA colonization in this population.",
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