Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III

Jong Lyul Park; Yeon Su Lee; Nawapol Kunkeaw; Seon Young Kim; In Hoo Kim; Yong Sun Lee

doi:10.2217/epi-2016-0108

Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III

Jong Lyul Park, Yeon Su Lee, Nawapol Kunkeaw, Seon Young Kim, In Hoo Kim, Yong Sun Lee

Biochemistry & Molecular Biology

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.

Original language	English (US)
Pages (from-to)	171-187
Number of pages	17
Journal	Epigenomics
Volume	9
Issue number	2
DOIs	https://doi.org/10.2217/epi-2016-0108
State	Published - Feb 2017

Keywords

RNA polymerase III
epigenetic regulation
nc886

ASJC Scopus subject areas

Genetics
Cancer Research

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title = "Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III",

abstract = "RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.",

keywords = "RNA polymerase III, epigenetic regulation, nc886",

author = "Park, {Jong Lyul} and Lee, {Yeon Su} and Nawapol Kunkeaw and Kim, {Seon Young} and Kim, {In Hoo} and Lee, {Yong Sun}",

note = "Funding Information: This work was supported by a Research Scholar Grant, RSG- 12-187-01 - RMC from the American Cancer Society to YS Lee, research grant no. 1610090 from the National Cancer Center to Y-S Lee. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: {\textcopyright} 2017 Yong Sun Lee. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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doi = "10.2217/epi-2016-0108",

language = "English (US)",

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AU - Park, Jong Lyul

AU - Lee, Yeon Su

AU - Kunkeaw, Nawapol

AU - Kim, Seon Young

AU - Kim, In Hoo

AU - Lee, Yong Sun

N1 - Funding Information: This work was supported by a Research Scholar Grant, RSG- 12-187-01 - RMC from the American Cancer Society to YS Lee, research grant no. 1610090 from the National Cancer Center to Y-S Lee. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: © 2017 Yong Sun Lee. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2017/2

Y1 - 2017/2

N2 - RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.

AB - RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.

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Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III

Abstract

Keywords

ASJC Scopus subject areas

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