Abstract
RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 171-187 |
| Number of pages | 17 |
| Journal | Epigenomics |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2017 |
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Keywords
- epigenetic regulation
- nc886
- RNA polymerase III
ASJC Scopus subject areas
- Genetics
- Cancer Research
Cite this
Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III. / Park, Jong Lyul; Lee, Yeon Su; Kunkeaw, Nawapol; Kim, Seon Young; Kim, In Hoo; Lee, Yong Sun.
In: Epigenomics, Vol. 9, No. 2, 01.02.2017, p. 171-187.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III
AU - Park, Jong Lyul
AU - Lee, Yeon Su
AU - Kunkeaw, Nawapol
AU - Kim, Seon Young
AU - Kim, In Hoo
AU - Lee, Yong Sun
PY - 2017/2/1
Y1 - 2017/2/1
N2 - RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.
AB - RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.
KW - epigenetic regulation
KW - nc886
KW - RNA polymerase III
UR - http://www.scopus.com/inward/record.url?scp=85010288043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85010288043&partnerID=8YFLogxK
U2 - 10.2217/epi-2016-0108
DO - 10.2217/epi-2016-0108
M3 - Review article
VL - 9
SP - 171
EP - 187
JO - Epigenomics
JF - Epigenomics
SN - 1750-1911
IS - 2
ER -