Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III

Jong Lyul Park, Yeon Su Lee, Nawapol Kunkeaw, Seon Young Kim, In Hoo Kim, Yong Sun Lee

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.

Original languageEnglish (US)
Pages (from-to)171-187
Number of pages17
JournalEpigenomics
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2017

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Keywords

  • epigenetic regulation
  • nc886
  • RNA polymerase III

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Park, J. L., Lee, Y. S., Kunkeaw, N., Kim, S. Y., Kim, I. H., & Lee, Y. S. (2017). Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III. Epigenomics, 9(2), 171-187. https://doi.org/10.2217/epi-2016-0108