Epithelial cells and their neighbors: I. Role of intestinal myofibroblasts in development, repair, and cancer

D. W. Powell, P. A. Adegboyega, J. F. Di Mari, R. C. Mifflin

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Intestinal myofibroblasts are α-smooth muscle actin-positive stromal cells that exist as a syncytium with fibroblasts and mural cells in the lamina propria of the gut. Through expression and secretion of cytokines, chemokines, growth factors, prostaglandins, and basal lamina/extracellular matrix molecules, as well as expression of adhesion molecules and receptors for many of the same soluble factors and matrix, myofibroblasts mediate information flow between the epithelium and the mesenchymal elements of the lamina propria. With the use of these factors and receptors, they play a fundamental role in intestinal organogenesis and in the repair of wounding or disease. Intestinal neoplasms enlist and conscript myofibroblast factors and matrix molecules to promote neoplastic growth, carcinoma invasion, and distant metastases.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume289
Issue number1 52-1
DOIs
StatePublished - Jul 2005

Fingerprint

Myofibroblasts
Epithelial Cells
Mucous Membrane
Intestinal Neoplasms
Neoplasms
Organogenesis
Giant Cells
Stromal Cells
Chemokines
Basement Membrane
Prostaglandins
Extracellular Matrix
Smooth Muscle
Actins
Intercellular Signaling Peptides and Proteins
Epithelium
Fibroblasts
Cytokines
Neoplasm Metastasis
Carcinoma

Keywords

  • Matrix molecules
  • Mesenchymal stem cells
  • Mesenchymal-epithelial interaction
  • Organogenesis
  • Stromal cells
  • Tumorigenesis
  • Wound repair

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Epithelial cells and their neighbors : I. Role of intestinal myofibroblasts in development, repair, and cancer. / Powell, D. W.; Adegboyega, P. A.; Di Mari, J. F.; Mifflin, R. C.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 289, No. 1 52-1, 07.2005.

Research output: Contribution to journalArticle

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