Epitope mapping with membrane-bound synthetic overlapping peptides

Terumi Midoro-Horiuti; Randall M. Goldblum

doi:10.1007/978-1-62703-992-5-25

Epitope mapping with membrane-bound synthetic overlapping peptides

Terumi Midoro-Horiuti, Randall M. Goldblum

Pediatrics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Epitope mapping with synthetic overlapping peptides is used for identifying epitopes of monoclonal antibodies (mAbs) and antibodies from patient sera (Midoro-Horiuti et al. Mol Immunol 43:509-518, 2006; Ivanciuc et al. J Agric Food Chem 51:4830-4837, 2003; Midoro-Horiuti et al. Mol Immunol 40:555-562, 2003; Wang et al. J Allergy Clin Immunol 125:695-702, 702.e1-702.e6, 2010). When the mAbs recognize epitopes that are also recognized by patients of interest, they may be useful as surrogates for patient antibodies.

Original language	English (US)
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	421-426
Number of pages	6
Volume	1131
ISBN (Print)	9781627039918
DOIs	https://doi.org/10.1007/978-1-62703-992-5-25
State	Published - 2014

Publication series

Name	Methods in Molecular Biology
Volume	1131
ISSN (Print)	10643745

Keywords

Antigen
Epitope
Monoclonal antibody
Overlapping peptides
Patient serum

ASJC Scopus subject areas

Molecular Biology
Genetics

Access to Document

10.1007/978-1-62703-992-5-25

Cite this

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AB - Epitope mapping with synthetic overlapping peptides is used for identifying epitopes of monoclonal antibodies (mAbs) and antibodies from patient sera (Midoro-Horiuti et al. Mol Immunol 43:509-518, 2006; Ivanciuc et al. J Agric Food Chem 51:4830-4837, 2003; Midoro-Horiuti et al. Mol Immunol 40:555-562, 2003; Wang et al. J Allergy Clin Immunol 125:695-702, 702.e1-702.e6, 2010). When the mAbs recognize epitopes that are also recognized by patients of interest, they may be useful as surrogates for patient antibodies.

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KW - Monoclonal antibody

KW - Overlapping peptides

KW - Patient serum

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ER -

Epitope mapping with membrane-bound synthetic overlapping peptides

Abstract

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Keywords

ASJC Scopus subject areas

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