Epizootiology of Hantavirus infections in baltimore: Isolation of a virus from Norway rats, and characteristics of infected rat populations

James E. Childs; George W. Korch; Gregory E. Glass; James W. Leduc; Keerti V. Shah

doi:10.1093/oxfordjournals.aje.a114662

Epizootiology of Hantavirus infections in baltimore: Isolation of a virus from Norway rats, and characteristics of infected rat populations

James E. Childs, George W. Korch, Gregory E. Glass, James W. Leduc, Keerti V. Shah

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Rats trapped from 14 locations In Baltimore, Maryland, were shown to have antibody to Hantavlrvs. Antibody prevalence rates were higher In residential locations than in parks. Infected rats were obtained continuously over a six-year period from 1980-1985 at five locations, indicating the enzootic nature of this infection In urban rats In the United States. Prevalence of antibody and geometric mean titers increased with rat mass and sexual maturity, suggesting that infections in rats are acquired through age-related mechanisms. Three isolates of Hantavlma were obtained from rats. One of these isolates was shown by serotoglc tests and monoclonal antibody reactivity patterns to be similar, if not identical, to rat virus previously obtained from Philadelphia. The presence of rats in many urban settings and the high prevalence of Hantavlms infection in this species suggest that human exposure to this virus is occurring In the United States, although human disease from this exposure has not been recognized.

Original language	English (US)
Pages (from-to)	55-68
Number of pages	14
Journal	American journal of epidemiology
Volume	126
Issue number	1
DOIs	https://doi.org/10.1093/oxfordjournals.aje.a114662
State	Published - Jul 1987
Externally published	Yes

Keywords

Disease reservolrs
Hemorrhagic fever, epidemic
Rattus norvogkus

ASJC Scopus subject areas

Epidemiology

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10.1093/oxfordjournals.aje.a114662

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title = "Epizootiology of Hantavirus infections in baltimore: Isolation of a virus from Norway rats, and characteristics of infected rat populations",

abstract = "Rats trapped from 14 locations In Baltimore, Maryland, were shown to have antibody to Hantavlrvs. Antibody prevalence rates were higher In residential locations than in parks. Infected rats were obtained continuously over a six-year period from 1980-1985 at five locations, indicating the enzootic nature of this infection In urban rats In the United States. Prevalence of antibody and geometric mean titers increased with rat mass and sexual maturity, suggesting that infections in rats are acquired through age-related mechanisms. Three isolates of Hantavlma were obtained from rats. One of these isolates was shown by serotoglc tests and monoclonal antibody reactivity patterns to be similar, if not identical, to rat virus previously obtained from Philadelphia. The presence of rats in many urban settings and the high prevalence of Hantavlms infection in this species suggest that human exposure to this virus is occurring In the United States, although human disease from this exposure has not been recognized.",

keywords = "Disease reservolrs, Hemorrhagic fever, epidemic, Rattus norvogkus",

author = "Childs, {James E.} and Korch, {George W.} and Glass, {Gregory E.} and Leduc, {James W.} and Shah, {Keerti V.}",

note = "Funding Information: Received for publication February 27, 1986, and in final form October 8, 1986. 1Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe Street, Baltimore, MD 21206. (Reprint requests to Dr. James E. Childs.) 1 Department of Epidemiology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD. This work was supported by contract DAMD17-84-C-4015 from the United States Army Medical Research and Development command. The authors thank Gregory Smith and Cynthia Rossi for technical assistance, and Anne Terry for help in the field. In conducting the research in this report, the investigators adhered to the Guide for the Care and Use of Laboratory Animals, as promulgated by the National Research Council.",

year = "1987",

month = jul,

doi = "10.1093/oxfordjournals.aje.a114662",

language = "English (US)",

volume = "126",

pages = "55--68",

journal = "American journal of epidemiology",

issn = "0002-9262",

publisher = "Oxford University Press",

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T1 - Epizootiology of Hantavirus infections in baltimore

T2 - Isolation of a virus from Norway rats, and characteristics of infected rat populations

AU - Childs, James E.

AU - Korch, George W.

AU - Glass, Gregory E.

AU - Leduc, James W.

AU - Shah, Keerti V.

N1 - Funding Information: Received for publication February 27, 1986, and in final form October 8, 1986. 1Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe Street, Baltimore, MD 21206. (Reprint requests to Dr. James E. Childs.) 1 Department of Epidemiology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD. This work was supported by contract DAMD17-84-C-4015 from the United States Army Medical Research and Development command. The authors thank Gregory Smith and Cynthia Rossi for technical assistance, and Anne Terry for help in the field. In conducting the research in this report, the investigators adhered to the Guide for the Care and Use of Laboratory Animals, as promulgated by the National Research Council.

PY - 1987/7

Y1 - 1987/7

N2 - Rats trapped from 14 locations In Baltimore, Maryland, were shown to have antibody to Hantavlrvs. Antibody prevalence rates were higher In residential locations than in parks. Infected rats were obtained continuously over a six-year period from 1980-1985 at five locations, indicating the enzootic nature of this infection In urban rats In the United States. Prevalence of antibody and geometric mean titers increased with rat mass and sexual maturity, suggesting that infections in rats are acquired through age-related mechanisms. Three isolates of Hantavlma were obtained from rats. One of these isolates was shown by serotoglc tests and monoclonal antibody reactivity patterns to be similar, if not identical, to rat virus previously obtained from Philadelphia. The presence of rats in many urban settings and the high prevalence of Hantavlms infection in this species suggest that human exposure to this virus is occurring In the United States, although human disease from this exposure has not been recognized.

AB - Rats trapped from 14 locations In Baltimore, Maryland, were shown to have antibody to Hantavlrvs. Antibody prevalence rates were higher In residential locations than in parks. Infected rats were obtained continuously over a six-year period from 1980-1985 at five locations, indicating the enzootic nature of this infection In urban rats In the United States. Prevalence of antibody and geometric mean titers increased with rat mass and sexual maturity, suggesting that infections in rats are acquired through age-related mechanisms. Three isolates of Hantavlma were obtained from rats. One of these isolates was shown by serotoglc tests and monoclonal antibody reactivity patterns to be similar, if not identical, to rat virus previously obtained from Philadelphia. The presence of rats in many urban settings and the high prevalence of Hantavlms infection in this species suggest that human exposure to this virus is occurring In the United States, although human disease from this exposure has not been recognized.

KW - Disease reservolrs

KW - Hemorrhagic fever, epidemic

KW - Rattus norvogkus

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Epizootiology of Hantavirus infections in baltimore: Isolation of a virus from Norway rats, and characteristics of infected rat populations

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